Shanghai Hengrui Pharmaceutical Co., Ltd.

Jiangsu Hengrui Medicine Company Ltd.

Jiangsu Hansoh Pharmaceutical Co., Ltd.

Jiangsu Hansoh Pharmaceuticals Co., Ltd.

Hejun Lü

Peng Cho Tang

Hongbo Fei

Yiqian Chen

Takuya Matsumoto

Fuqiang Zhao

Zhigang Lin

Li Ping Wang

Wei Zhang

Li Wang

Fanglong Yang

Guangyuan Shen

Dongliang Guan

Hao Zheng

Shenglan Wang

Jianghong Fu

Pengcho Tang

The pharmaceutically acceptable salts of bicycle-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description. 

Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof

The pharmaceutically acceptable salts of bicyclo-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description. 

The invention provides derivatives of azabicyclo alkane having formula (ID), and the method for making them, wherein each substitute in formula (ID) is same as defined in the description. 

Dicycloazaalkane derivatives, preparation processes and medical uses thereof

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description. 

Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof

Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions.

Derivatives of azabicyclo octane, the method of making them and the uses thereof as inhibitors of dipeptidyl peptidase IV

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Shanghai, China

Hejun Lü