Other

Kureha Chemical Industry Company, Limited

Daiichi Radioisotope Laboratories, Ltd.

Yamagata Technopolis Foundation

Heitaro Obara

Satoru Kumazawa

Masaaki Aoyama

Takashi Igarashi

Hidekatsu Yokoyama

Tetsuo Oi

Osamu Itoh

Kazuhisa Sakurai

N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor

A medicine or reagent comprising a bipyrazole derivative of the following formula (I), ##STR1## wherein R.sub.1 and R.sub.2 are individually a hydrogen atom, aryl group, alkyl group having 1-5 carbon atoms, or alkoxycarbonylalkyl group having a total of 3-6 carbon atoms, R.sub.3 and R.sub.4 are individually a hydrogen atom, alkyl group having 1-5 carbon atoms, cycloalkyl group having 5-7 carbon atoms, hydroxyalkyl group having 1-3 carbon atoms, benzyl group, naphthyl group, or substituted or unsubstituted phenyl group, as an active component. The medicine is useful for effectively capturing active oxygen and free radicals which cause adult diseases such as cerebral ischemia, heart disease, digestive system disease, and carcinoma, as well as inflammation, and for diagnosing diseases associated with in vivo free radicals.

Bipyrazole derivative, and medicine or reagent comprising the same as

Derivatives of alkyl 3-(substituted or unsubstituted benzylidene)-1-alkyl-2-oxocylopentanecarboxylate of the following formula (I), ##STR1## wherein R.sup.1 and R.sup.2 individually represent a lower alkyl group; X is a halogen atom, a cyano group, an alkyl group, a haloalkyl group, a phenyl group, or a nitro group; and m is an integer of 0 to 5; provided when m is 2 or larger, Xs may be either the same or different. The compounds are useful themselves as an effective ingredient of antifungal compositions, and can be used for intermediates of agriculture chemicals and medicines.

Alkyl 3-(substituted or unsubstituted

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Sendai, Japan

Heitaro Obara