Hoechst Aktiengesellschaft

Sanofi-a Ventis Deutschland Gmbh

Aventis Pharma Deutschland, Gmbh

Heinz-Werner Kleeman

Udo Albus

Hans-Jochen Lang

Hansjorg Urbach

Joachim Brendel

Bernward Scholkens

Wolfgang Scholz

Heinrich Christian Englert

Hans Jochen Lang

Bansi Lal

Dieter Ruppert

Anil Vasantrao Ghate

The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I: and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable salts thereof.

Pentafluorosulfanylphenyl-substituted benzoylguanidines, method for the production thereof, their use as a medicament or diagnostic agent, and a medicament containing these compounds

Substituted 1-naphthoylguanidines, process for their preparation, their use as a medicament or diagnostic , and medicament containing them

Benzoylguanidines of the formula I are described ##STR1## in which R(1)=hydrogen, Hal, --NO.sub.2, --C.tbd.N, --CF.sub.3, R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, R(4) and R(5) are alk(en)yl or CF.sub.3, R(5) also having the meaning of H,

Substituted benzoylguanidines, process and their preparation, their use

The invention relates to compounds of the formula 1 ##STR1## in which A.sup.1 denotes a radical of the formulae ##STR2## A.sup.2 is absent or represents a radical of the formula ##STR3## R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and X and Y, independently of one another, represent --O-- or --NR.sup.13 --, and to the salts thereof. Also described is a process for the preparation of the compounds of the formula 1, corresponding pharmaceutical products, and the use thereof as medicines, and intermediates for the preparation of these compounds.

Renin inhibitors

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Bischofsheim, Germany

Heinz-Werner Kleeman