Sandoz Gmbh

Novartis Ag

Heinz Sucker

Martin List

Peter Gassmann

Alain De Buman

Aldo Riva

Particles of a substantially water insoluble biologically active substance, such as Cyclosporin, are loaded with a charged glyceryl ester as an electrostatic stabilizer which imparts to the particles a zeta potential and having an active substance:stabilizer weight ratio of 1:1 to 400:1 and an average particle diameter of 1 nanometer to 10 micrometers. Compositions having such particles are found to be useful delivery systems.

Pharmaceutical compositions comprised of stabilized peptide particles

The invention provides a hydrosol of a pharmacological active agent in an intravenous applicable, stabilised, pharmaceutically acceptable form, which form is suspended or is dry and re-suspendable in an aqueous medium. The hydrosol contains solid active agent particles, e.g. of dihydropyridines or cyclosporines.

Hydrosols of pharmacologically active agents and their pharmaceutical

This invention provides a compression process for the production of suppositories characterized in that the compression step is effected at a temperature at or below +10.degree. C., and in the absence of a binding agent.

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Basel, Switzerland

Heinz Sucker