Aventis Pharmaceuticals Inc.

Heinz Pauls

Julian Roy Levell

Peter Charles Astles

Yong Gong

Paul R Eastwood

Kent W Neuenschwander

Mark Czekaj

Olivier Houille

Guyan Liang

James R Pribish

This invention relates to compounds of formula which inhibit Factor Xa or tryptase, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa or tryptase.

1-aroyl-piperidinyl benzamidines

Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.

Chemical compounds

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Flemington, NJ, United States of America

Heinz Pauls