Biotronik Vi Patent Ag

Biotronik Ag

Biotronik Mess-und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin

Biotronik Mess-und Therapiegeraete Gmbh & Co.

Biotronik Mass-und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin

Cortronik Gmbh

Heinz Mueller

Peter J Uggowitzer

Joerg Loeffler

Claus Harder

Bodo Gerold

Bernd Heublein

Anja Haenzi

Max Schaldach

Curt Kranz

Daniel Lootz

Alexander Borck

Klaus-Peter Schmitz

Alexander Rzany

Detlef Behrend

Niels Grabow

Carsten Momma

Ellen Korzuschnik

Dietmar Esperschidt

Gerhard Kappelt

Michael Teske

Sabine Illner

Jonathan Ortelt

Daniela Arbeiter

Stefan Oschatz

Peter Uggowitzer

A method for producing a magnesium alloy having improved mechanical and electrochemical properties. The method includes generating a high-purity magnesium by vacuum distillation. A billet of the alloy is generated by synthesis of the high-purity magnesium with 2.0 to 10.0% by weight Al, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, wherein the matrix of the alloy includes intermetallic phases formed of Mg and Al. The alloy is homogenized by annealing at a temperature between 150° C. and 450° C. The homogenized alloy is formed in the temperature range between 200° C. and 400° C.

Method for producing magnesium alloy

A magnesium alloy includes &#x3c;3% by weight of Zn, &#x2264;0.6% by weight of Ca, with the rest being formed by magnesium containing impurities, which favor electrochemical potential differences and/or promote the formation of intermetallic phases, in a total amount of no more than 0.005% by weight of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloy contains elements selected from the group of rare earths with the atomic number 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.002% by weight.

Magnesium-zinc-calcium alloy and method for producing implants containing the same

A preferred embodiment is an uncoated, biodegradable stent. The stent has a filigree structure of magnesium alloy struts. The struts of the supporting structure are arranged to permit a compressed form for introduction into the body and to permit an expanded form at the site of the application within a vessel. The magnesium alloy struts are formed of a corrodible magnesium alloy. The magnesium alloy is formed from high-purity vacuum distilled magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases. The impurities are such that the struts of the stent have a tensile strength of &#x3e;275 MPa a yield point of &#x3e;200 MPa, a yield ratio of &#x3c;0.8, a difference between tensile strength and yield point of &#x3e;50 MPa.

Corrosion resistant stent

A preferred embodiment is an uncoated, biodegradable corrosion resistant bone implant. The implant includes a body being uncoated and lacking any protective polymer, metallic or ceramic coating, the body being shaped to fix to a bone and/or bone fragment. The body is formed of a magnesium alloy. The magnesium alloy includes from high-purity vacuum distilled magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases. The impurities are such that the body has a strength of &#x3e;275 MPa, and a ratio yield point of &#x3c;0.8, wherein the difference between strength and yield point is &#x3e;50 MPa.

Uncoated biodegradable corrosion resistant bone implants

A magnesium alloy, implants and method for the production thereof. The magnesium alloy includes 1.5 to 7.0% by weight Zn, 0.5 to 3.5% by weight Al, the remainder being magnesium which contains impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P.

Magnesium alloy, method for the production thereof and use thereof

A magnesium alloy includes 3 to 7.0% Zn, 0.001 to 0.5% Ca, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of intermetallic phases, in a total amount of no more than 0.005 of Fe, Si, Mn, Co, Ni, Cu, Al, Zr and P, wherein the alloying elements are selected from the group of the rare earths having the ordinal numbers 21, 39, 57 to 71 and 89 to 103 in a total amount of no more than 0.001% by weight.

Magnesium-zinc-calcium alloy, method for production thereof, and use thereof

A medical implant comprising a composite material which is composed of reinforcement fibers made of a magnesium-containing, bio-corrosive alloy, another bio-corrosive alloy containing a main component that is selected from the group consisting of Mg, Ca, Fe, and Y, or a non-biodegradable fiber material, embedded in a matrix made of crystalline magnesium or magnesium alloys.

Absorbable medical implant made of fiber-reinforced magnesium or fiber-reinforced magnesium alloys

The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar)

Implant of low radial strength

A magnesium alloy having Y, Zn, Ca, Mn, Ag, Ce, Zr, or Si. The alloy is distinguished in that, in the event of suitable treatment, the alloy is convertible into a very fine-grained microstructure, in particular, having grain sizes less than 20 &#x3bc;m. The alloy components are not or are hardly toxicologically relevant.

Magnesium alloy

A biocorrodible implant includes a base formed from magnesium or a biocorrodible magnesium alloy, whose surface has a corrosion-inhibiting coating. A diffusion layer, which covers the base, differs in composition from the implant material. The diffusion layer contains at least one metallic element of the implant material and at least one corrosion-inhibiting element selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE, where RE stands for rare earth metals. The implant optionally includes a metal layer of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer, and a passivating layer of metal oxides, metal nitrides or metal fluorides of at least one of the corrosion-inhibiting elements selected from the group of Al, Zn, Ca, Si, In, Mn, Sc and RE covering the diffusion layer or the metal layer.

Biocorrodible implant having a corrosion-inhibiting coating

An endoprosthesis includes a carrier structure which contains a metallic material. The metallic material contains a magnesium alloy of the following composition: magnesium: &#x3e;90%, yttrium: 3.7%-5.5%, rare earths: 1.5%-4.4% and balance: &#x3c;1%.

Endoprosthesis

A base body for an implant comprising a biocorrodible iron alloy including at least one of the following: (i) a biocorrodible iron alloy of formula Fe&#x2014;P where P is 0.01-5 wt %, and Fe plus impurities account for the remainder up to 100 wt %; or (ii) a biocorrodible iron alloy of formula Fe&#x2014;Mn&#x2014;X where Mn is 5-30 wt %, X is at least one of Pt, Pd, Ir, Rh, Re, Ru and Os, and X is 0-20 wt % and Fe plus impurities account for the remainder up to 100 wt %; or (iii) a biocorrodible iron alloy of formula Fe&#x2014;Z where Z is at least one of Pt, Ir and Os and Z is 5-30 wt %, and Fe plus impurities account for the remainder up to 100 wt %.

Implant with a base body of a biocorrodible iron alloy

A magnesium alloy, comprising: wherein the amounts are based on weight-percent of the alloy and Mg, and manufacturing-related impurities constitute the remainder of the alloy to a total of 100 weight-percent. Also disclosed is a method for manufacturing such an alloy and a biodegradable implant formed therefrom.

Magnesium alloy and the respective manufacturing method

An implant comprising an implant material forming a base made of one or more metallic elements; a diffusion layer covering the base made of at least one of the metallic elements of the implant material and at least magnesium; and, optionally, a metal layer covering the diffusion layer made of magnesium or a biocorrodible magnesium alloy.

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Erlangen, Germany

Heinz Mueller