Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Roche Molecular Systems, Inc.

F. Hoffmann-la Roche Ag

Heinz-Michael Hein

Frank Deck

Carlo S Effenhauser

Rainer Jaeggi

Karl-Heinz Koelker

Dirk Boecker

Emad Sarofim

Uwe Kraemer

Irio Giuseppe Calasso

Patrick Griss

Matthias Essenpreis

Hans-Peter Haar

Stephan Korner

Reto Abt

Rudolf Reiter

Hans List

Elmar Bosies

Wolfgang Petrich

Hans-Juergen Kuhr

Goran Savatic

Edwin Oosterbroek

Michael Glauser

Hans-Peter Wahl

Norbert Gretz

Gerhard Werner

Oliver Gutmann

Lotar Schenk

Michael Andreas Heinrich

Dietmar Volz

Marcus Hermann

Carsten Deus

Hans Peter Josel

A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

System for the analysis of liquid samples

A system is provided for withdrawing small amounts of body fluid from an animal or human. The system includes a holder and a disposable lancing unit attached to the holder. The lancing unit also includes an open capillary channel for transporting the body fluid and piercing the skin.

System for withdrawing small amounts of body fluid

The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.

Method and device for the extraction of a body fluid

The present invention includes a container and a method of separating one or more components of interest bound to magnetic particles using centrifugal forces.

Methods and device employing centrifugal force

The invention relates to a method for creating a puncture wound for obtaining a sample of a body fluid from a body part in which a skin opening is created at a puncture site in the epidermis in a skin-opening step. Then, in a sample collection step a sample collection puncture is executed by using a puncture element with which the skin opening is deepened with the puncture element, thereby creating a puncture wound for obtaining the sample. The invention also relates to a handheld apparatus for implementing this method.

Handheld apparatus for creating a puncture wound

On an analytical device for photometric analysis of chemistry and/or fluid samples comprising a rotatable disk-like body, a plurality of receptacles for fluid samples and optics for guiding light beams through the receptacles are arranged. At least part of the optics are designed and/or arranged such that at least part of the light beams is deflected and guided through the receptacles at an angle to the radially outward direction on the disk-like body which means at an angle to the radius, connecting the respective optics with the rotation axis of the disk-like body.

Photometric analysis of biological samples using in-plane detection

A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values. For the selective determination of the scattering coefficient, the evaluation algorithm includes a step in which a time derivative value &#x394;I(r) describing the change of the measurement intensity value versus time is calculated from intensity measurement values obtained at a minimum of two different points of time.

Method for the determination of a light transport parameter in a biological matrix

The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.

Quantification of disease progression by means of interpolation between parameters based on electromagnetic spectra

A method for the selective determination of the scattering index &#x3bc;of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of which light in the form of primary light () is irradiated into the biological matrix () and an intensity measurement value of secondary light () exiting at a detection site (-) that is located at different measuring distances (&#x3c1;) from the respective light irradiation site () during the detection measurements is measured. In order to improve the quality and selectivity of the determination of &#x3bc;, the primary light is irradiated obliquely at an angle between 5&#xb0; and 85&#xb0; using a contacting light-guiding element. In at least two detection measurements, the measuring distance (&#x3c1;) between the respective light irradiation site () and the respective detection site (-) corresponds to no more than five times the mean free path length of the light propagating in the biological matrix.

Method and device for determining a light transport parameter in a biological matrix

The present invention generally relates to a system for withdrawing small amounts if body fluid from an animal or human. The system comprises a holder and a disposable lancing unit attached to the holder. The lancing unit also comprises an open capillary channel for transporting the body fluid and piercing the skin.

The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent.

Fluorescent isothiocyanate (fitc) sinistrin, its production and use

New dye-polysaccharide and dye-cyclosaccharide conjugates and their use as a diagnostic agent especially for determining the glomerular filtration rate in humans.

Dye-polysaccharide conjugates and their use as a diagnostic agent

Growing community of inventors

Weinheim, Germany

Heinz-Michael Hein