Hoechst Aktiengesellschaft

Heinz Loewe

Reinhard Kirsch

Dieter Duwel

Josef Urbanietz

Manfred Rosner

Wolfgang Raether

New phenylsulfonyloxybenzimidazolecarbamates of the formula ##STR1## are described, as are processes for their preparation. The new compounds have anthelmintic activity, including, in particular, against liver flukes.

Substituted phenylsulfonyloxybenzimidazolecarbamates and anthelmintic

New benzenesulfonic esters of the formula I ##STR1## and a process for their preparation are described. The new compounds are active against helminths and can thus be used as agents to counter worms in humans and animals.

Substituted benzenesulfonic esters and their use as medicaments for

New monocarboxylates of phenylguanidinesulfonic acid esters and a process for their manufacture are described. They are effective as medicaments against helminths and liver flukes when administered orally or parenterally.

Monocarboxylates of phenylguanidinesulfonic acid esters, a process for

2-Carbalkoxyamino-benzimidazolyl-5(6)-sulfonic acid phenyl esters are disclosed as well as a process for their manufacture. The new compounds have valuable chemotherapeutic properties and are suitable for combating diseases caused by parasites in humans and animals, such as helminths and liver flukes.

3,4-Diaminophenyl sulfonic acid esters

Substituted phenylguanidines are disclosed as well as a process for their manufacture. The said compounds are active against helminths and liver flukes.

Substituted phenylguanidines and process for their manufacture

Substituted bis-benzimidazolyl compounds of the formula ##STR1## are disclosed, wherein A is thiophenediyl, furanediyl, phenylene, or phenoxyphenylene, and R.sup.1 is ##STR2## where R.sup.2 -R.sup.10 are independently hydrogen, alkyl, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, or phenyl, or any two of R.sup.2 -R.sup.10 taken together are C.sub.2 -C.sub.4 alkylene, as are methods of making the compounds, which are useful as chemotherapeutic agents in the treatment of protozoal and viral diseases.

Substituted bis-benzimidazolyl compounds; preparation and use thereof

3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives are disclosed as well as a process for their manufacture. The compounds are suitable for combatting helminths and especially gastrointestinal Strongylides and liver flukes.

3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives

Anthelmintically active basically substituted 2-carbalkoxy-amino-benzimidazolyl-5(6)-phenyl ethers and -ketones are disclosed as well as a process for preparing them. The compounds are chemotherapeutics having a particular activity against ankylostomes, other helminths as well as liver fluke.

Anthelmintically active basically substituted

Anthelmintically active 2-carbalkoxyamino benzimidazolyl-5(6)-sulfonic

2-Carbalkoxyamino-5(6)-phenyl sulfonyloxy benzimidazoles are disclosed as well as a process for their manufacture. The new compounds are valuable chemotherapeutic agents and are suitable for combating diseases caused by parasites in humans and animals, such as helminths and liver flukes.

Anthelmintically active 2-carbalkoxyamino-5(6)-phenyl sulfonyloxy

2-Carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers of the formula (I) ##SPC1## in which R.sub.1 represents alkyl of 1 to 4 carbon atoms, R.sub.2 and R.sub.3 represent, independently of each other, hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms or carbalkoxy of 1 to 4 carbon atoms in the alkoxy group, R.sub.4 represents hydrogen or chlorine and X represents oxygen or sulfur as anthelmintically active compounds in pharmaceutical preparations and a method for using the same.

Anthelmintically active 2-carbalkoxy-amino-benzimidazole-5(6)-phenyl

2-Carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers of the formula (I) ##SPC1## in which R.sub.1 represents alkyl of 1 to 4 carbon atoms, R.sub.2 and R.sub.3 represent, independently of each other, hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms or carbalkoxy of 1 to 4 carbon atoms in the alkoxy group, R.sub.4 represents hydrogen or chlorine and X represents oxygen or sulfur, useful as anthelmintics.

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Kelkheim, Germany

Heinz Loewe