Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Heinz Kurt Macho

Michael Fritz

Herbert Harttig

Gerhard Bienhaus

Edda Geisler

Jurgen Schwab

Rolf Lerch

Volker Zimmer

Wolfgang Werner

Hans Lange

Dieter Berger

Uwe Ruppender

Werner Poppe

Klaus Dieter Hungenberg

Rainer Van Rijekevorsel

Peter Vogel

Rainer Van Rijckevorsel

Klaus Nenninger

Joachim Kasielke

Peter Schafer

Norbert Becker

Georg Arras

Alfred Schaffner

Helmut Rinkel

J&uuml;rgen Schwab

Method of isolating a biological material

Dispensing device for dispensing small quantities of fluid comprising a compressible balloon with an end-to-end capillary inserted within the walls of the balloon in such a way that the one end of the capillary communicates with the interior of the balloon and the other end of the capillary communicates with the exterior space. The balloon has at least one opening through which the interior space of the balloon communicates with the exterior space. The at least one opening has a flow resistance that is designed so that a fluid contained in the capillary is expelled when the balloon is compressed. The present invention also comprises a system and method for the metered dispensing of fluids.

Dispensing device for dispensing small quantities of fluid

Subject matter of the invention is a method of binding a biological material to a solid phase by providing a sample liquid containing the biological material in a sample vessel (A) having an inner contour (A17); then a hollow body (C) which has a contour (C12) that matches the inner contour (A17) is introduced into the sample vessel (A) while being closed with respect to the sample vessel by means of a porous matrix (C11); the sample liquid can enter the structural form (C) through the porous matrix (C11). This method is easy to automate and reduces the generation of aerosols.

Method of binding a biological material

A lid for closing an opening of a vessel includes a lid body configured to engage the opening, with the vessel having a defined shape. The lid body includes an engagement part which engages a corresponding surface of the vessel, thereby closing the opening. A handling element is disposed on an outer portion of the lid, with the handling element extending in parallel with an axis of the vessel. The handling element is for handling the lid for opening and closing the vessel.

Lid for closing vessels

A system for the temperature adjustment treatment of liquids, especially during the isolation and amplification of nucleic acids with a reusable thermostat element and a disposable heating element has the advantage of a particularly simple means of conducting temperature adjustment treatments. This system facilitates the execution of sample preparation and amplification in a single vessel.

System for the temperature adjustment treatment of liquid samples

A vessel for reducing contamination of liquids is formed of a vessel body with an inlet opening and an outlet opening therein. A closing device is attached to the vessel body adjacent the outlet opening. The closing device closes the outlet opening, and includes a normally closed one-way valve which is openable by a predetermined pressure from within the vessel body.

Vessel for reducing contamination in the treatment of liquids

The invention concerns a diagnostic test carrier (1) containing a supporting layer (2) with a detection layer (3) arranged thereon containing reagents required for the determination of an analyte in a liquid sample and an inert layer (4) covering the detection layer (3) wherein the inert layer (4) is arranged at such a distance (5) from the detection layer to enable a capillary active liquid transport between the detection layer and inert layer (3,4), characterized in that the inert layer (4) extends beyond the detection layer and wherein the area (10) that extends beyond the detection layer is attached to the supporting layer (2) in such a way that a continuous capillary active liquid transport between the inert layer and detection layer (4,3) and between the inert layer and supporting layer (4,2) is possible and in addition the inert layer (4) contains several holes (7) in the area of the detection layer (3) through which the sample to be examined and the components contained therein can be applied to the detection layer (3) as well as its use for the determination of an analyte in a liquid.

Diagnostic test carrier with a capillary gap

Two absorbent layer materials for a sample liquid are connected with one another in such a way that the sample liquid can pass through from one layer into the other layer through the connecting surface between the layers a hot melt adhesive is applied to the first layer material in the form of a discontinuous coating and the second layer material is pressed on while the melt adhesive is still sufficiently hot. The amount of the melt adhesive and the pressing-on force are adjusted to one another with regard to the surface properties in such a manner that, even after the application and pressing on of the second layer material, a continuous liquid-permeable melt adhesive layer does not result. The diagnostic test carrier for the investigation of a sample liquid has two absorbent layers arranged over one another so that the sample liquid can pass through the connecting surface between the layers from one layer into the other, wherein the absorbent layers are connected with one another by a discontinuous liquid-permeable melt adhesive layer.

Process for the preparation of a diagnostic test carrier and the carrier

A sample application zone and detection zone are arranged on a pile-like complex made of a fleece and a porous membrane which are in a direct or indirect contact that enables passage of liquid through the contact area and the membrane is a polyamide, polyvinylidene difluoride, polyether sulfone or polysulfone membrane which transports liquid significantly slower over the area than the fleece.

Multilayer analytical element for the determination of an analyte in a

An analytical device is used for the determination of an analyte in a liquid sample. The device includes a fleece layer including fleece material and polyester fibers, and a reagent for determining an analyte. The reagent is for entering into a detectable reaction with the analyte. The polyester fibers are heat-meltable copolyester fibers containing terephthalic acid, isophthalic acid, and 1,4-butanediol.

Analytical method and device containing a fleece layer

An analytical device determines the analytes in a liquid sample. This device includes a layer of flat material which has a sample application area and a detection area thereupon. The detection area includes a reagent for determining the analyte, and the absorbent sample application area and the absorbent detection area are disposed within a liquid impermeable boundary. The layer of flat material also includes an absorbent connector which is disposed such that the sample application area and the detection area are connected by the absorbent connector. The liquid impermeable boundary and the absorbent connector prevents liquid from being transported between the sample application area and the detection area, except through the absorbent connector.

Test carrier for the determination of an analyte as well as a process

At least two layers are fixed together at a distance so that a gap is present between them, wherein the layers are connected with one another by a plurality of discrete melt adhesive regions, intermediate spaces being present between the melt adhesive regions so that a liquid transport in the gap between the layers is assured through the intermediate spaces. To produce this test carrier, the melt adhesive in the form of discrete regions, between which intermediate spaces are present, is applied to a first layer material in a thickness which is greater than the desired gap and a second layer material is pressed against the melt adhesive regions while the melt adhesive is still sufficiently hot in order to be bindable in such a manner that it binds with the melt adhesive but a gap remains between the layer materials.

Diagnostic test carrier

An analysis test strip and a process for the production of analysis test strips with a longitudinal carrier upon which is fixed at least one test field. The test field material is produced batchwise in an amount sufficient for a plurality of test strips, and thereafter, in a chronologically separate working step, is continuously fixed in the form of at least one band onto a parallel-running substantially wider band of test strip carrier material. The band as a whole is cut up transversely to its longitudinal direction into a plurality of test strips. Prior to the cutting up, a bar code is applied to the carrier band running parallel to the edges thereof of such high information density that it is suitable as a store of batch-specific information necessary for the quantitative evaluation of the reaction which has previously been obtained by investigation of the test field material of one batch.

Analysis test strip

Method of and apparatus for making a test strip and a test strip made by such method having a longitudinally extending carrier and a test field thereon. The carrier has a layer of magnetizable material thereon in which an amount of data for the storage of information has been applied in the longitudinal direction of the magnetizable material. The carrier has a recess near each end thereof adapted to provide a required alignment and positioning of the strip.

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Furth/Fahrenbach, Germany

Heinz Kurt Macho