Roche Diagnostics Operations, Inc.

Avl Medical Instruments Ag

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Heinz Kontschieder

Christoph Boehm

Sascha Lutz

Christoph Ritter

Gregor Ocvirk

Bernhard Schaffar

Miriam Ruf

Wolfgang Burkhardt

Hermann J Marsoner

Helmut List

Helmut Offenbacher

Herfried Huemer

Falko Skrabal

Wolfgang Huber

Martin Hajnsek

Andreas Martin Dolezal

Marco Jean Pierre Leiner

Marie-Luise Schinnerl

Johann Harer

Franz-Josef Krysl

Marco Jean-Pierre Leiner

Franz Josef Krysl

The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.

Sensor assembly

The invention concerns a sensor cassette that can be inserted into an analyzer comprising a continuous measuring channel for receiving fluidic media and sensory elements for determining chemical and/or physical parameters of the fluidic media. According to the invention the sensor cassette consists of at least two permanently connected but separately manufactured modules which each have a housing and a measuring channel section wherein the measuring channel sections of adjacent modules are connected to the continuous measuring channel by a fluidic coupling and wherein at least one of the connected modules is designed as a sensor module and has a sensor array comprising at least two sensory elements. Furthermore, a memory element is allocated to the sensor cassette on which specific information for the sensor cassette in particular with regard to its construction from the respective modules is stored.

Modular sensor cassette

The invention relates to a method and device for the monitoring of a medical microsample in the flow measuring cell of an analyzer with regard to position and absence of bubbles by means of an alternating voltage applied to the measuring cell, the measuring cell being provided with a multitude of electrode systems placed one behind the other, each system comprising a number of single electrodes for measuring a substance contained in the microsample by means of a measurement voltage which essentially is a DC voltage. To monitor the exact position of the microsample and/or to detect air bubbles in the area of each electrode system, the alternating voltage and the measurement voltage are simultaneously and directly applied to the single electrodes of the corresponding electrode system, and the measured AC component respectively the measured impedance gives a measure for the position of the microsample and the absence of bubbles.

Method and a device for monitoring a medical microsample in the flow measuring cell of an analyzer

A planar sensor for determining a chemical parameter of a sample, includes a substrate whose surface is at least partly plane and is provided with at least one potentiometric or amperometric and, possibly, an optical transducer, and one or more biochemical components. The transducer and the biochemical component are provided on the surface of the substrate, or at least part of the surface, as a sensor spot, and a cover membrane surrounding this sensor spot, is heat welded to the surface of the substrate. Those sensor spots that include a potentiometric or amperometric transducer are in contact with a strip conductor attached to the plane surface of the substrate and the thermal seal of the cover membrane is interrupted where the conducting strips lead away from the sensor spots.

Planar sensor for determining a chemical parameter of a sample

In order to produce a small-volume flow measuring cell with good flow characteristics in a sensor device for determining the concentration of a substrate in a sample medium, comprising an enzyme electrode which is covered by a membrane and a reference electrode, both of which are in contact with the measuring cell, the proposal is put forward that the reference electrode be located outside of the membrane cover of the enzyme electrode and that the maximum extension of the flow measuring cell normal to the flow direction of the sample medium essentially be the same as the diameter of the sensitive layer of the enzyme electrode.

Sensor device

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Graz, Austria

Heinz Kontschieder