Novozymes A/s

Novo Nordisk Pharmaceuticals, Inc.

Heinz-Josef Deussen

Soren Ebdrup

Magali Zundel

Shamkant Anant Patkar

Palle Schneider

Arne Agerlin Olsen

Peter Rahbek Ostergaard

Carsten Mailand Hjort

Charlotte Johansen

Erwin Ludo Roggen

Tine Muxoll Fatum

Soren Christensen

An esterase isolated fromis capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology to known amino acid sequences.

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The present invention relates to a process comprising hydrolysis or trans esterification of one of the two enantiomeric forms of a racemic or enantiomerically enriched ester of formula I or IV by a higher rate than the other by an enzyme to give an ester and a acid (III) or two different esters (V) and (VI) with different R groups both with increased enantiomeric purity and a esterification process of a racemic or enantiomerically enriched acid (VII) by an enzyme to give an ester and an acid both with increased enantiomeric purity.

Process for the preparation of substituted 3-phenyl-propanoic acid esters and substituted 3-phenyl-propanoic acids

A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EO PO wherein EO is ethylene oxide, PO is propylene oxide, x&equals;1&minus;99%, y&equals;1&minus;99%, x&plus;y&equals;100%, and x and y are in a ratio range of 10:90 to 90:10, more preferably 40:60 to 60:40, or in a 50/50 ratio. The polymer, which can be a block polymer, typically has a molecular weight in a range of 100 to 100,000 daltons, and the polypeptide may contain 1 to 100 polymer molecules. Coupling the polypeptide, in particular enzymes, to the polymer reduces respiratory allergenicity of the polypeptide. Industrial compositions such as detergent compositions, personal care compositions, compositions for processing/treating textiles, and food and feed compositions containing the polypeptide-polymer conjugate have reduced respiratory allergenicity.

Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity

The present invention relates to an enzymatic composition capable of killing or inhibiting microbial cells or micro-organisms, e.g. in laundry, on hard surfaces, in water systems, on skin, on teeth or on mucous membranes. The present invention also relates to the use of said enzymatic composition for preserving food products, cosmetics, paints, coatings, etc.

Antimicrobial composition containing an oxidoreductase and an enhancer of the N-hydroxyanilide-type

Methods and compositions for bleaching a dye in solution

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Soborg, Denmark

Heinz-Josef Deussen