Forschungszentrum Julich Gmbh

Kernforschungsanlage Julich Gesellschaft MIT Beschrankter Haftung

Heinz Hubert Coenen

Christian Wandrey

Udo Kragl

Kurt Hamacher

Andreas Liese

Gerhard Stoecklin

Thomas Tierling

Juliane Beliczey

Peer Kling

Furanosides or pyranosides can be reacted with pyruvate and converted into sialic acids in good yields by an enzymatic synthesis, using a suitable aldolase, where the concentration of aldolase, per 50 mM of pyruvate, is 1 to 2,500 U*/ml. For example, 3-fluoroneuraminic acid and other 3,3-didesoxy-3-fluorononulopyranosonic acid derivatives can be prepared in this manner. The F-atom in the resulting sialic acid (which can be F or F and F) provides a label which makes possible studies of mammalian physiology and diagnosis of mammalian diseases.

Method for making fluorinated sugars having a side chain and use thereof

The use of 2-radiohalogenotyrosine derivatives of the formula I ##STR1## in which X denotes a radioactive halogen, in particular fluorine-18, bromine-75 or iodine-123, and R denotes hydrogen or methyl, in particular of 2-fluoro(18)-tyrosine and -methyltyrosine (II) for emission-tomographic measurement of protein synthesis in vivo, in particular for the purposes of cerebral diagnosis, by means of SPECT and, in particular, by means of PET, provides, in view of the particularly high incorporation rate, especially of II, the possibility of quantitative kinetic evaluation and is thus of great interest, specifically in the framework of tumor diagnosis.

Radiofluoro-tyrosine derivatives, the preparation and use thereof

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Grevenbroich, Germany

Heinz Hubert Coenen