Gruenenthal Gmbh

Grunenthal Gmbh

Bayer Pharma Aktiengesellschaft

Heinz Graubaum

Werner Guenter Englberger

Bernd Sundermann

Stefan Oberboersch

Beatrix Merla

Hagen-Heinrich Hennies

Helmut Sonnenschein

Hans Schick

Klaus Linz

Stefan Schunk

Wolfgang Schröder

Bert Nolte

József Bálint

Sigrid Ozegowski

Melanie Reich

Saskia Zemolka

Fritz Theil

Edward Bijsterveld

Birgit Braun

Timo Struenker

Philip Lienau

Ulrich Klar

Gerhard Siemeister

Hans Briem

Knut Eis

Babette-Yvonne Koegel

Lars Bärfacker

Ruth Jostock

Achim Kless

Volker Schulze

Derek John Saunders

Wilhelm Bone

Claudia Hinze

Simon Holton

Sabine Hees

Michael Gruss

Marion Hitchcock

Keith Graham

Stefanie Frosch

Utz-Peter Jagusch

Petra Bloms-Funke

Sven Frormann

Jens Schröder

Carsten Griebel

Stefan Oberbörsch

Babette-Yvonne Kögel

René Tempel

Birgit Roloff

Jozsef Bálint

Stephan Schunk

Timo Strünker

Lars BÄRFACKER

Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals. 

3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones

The invention relates to compounds that have an affinity to the &#x3bc;-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.

Substituted 4-aminocyclohexane derivatives

Spirocyclic cyclohexane compounds corresponding to formula I In which R, R, Rand Rthrough Rand X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the &#x3bc;-opioid receptor.

Spirocyclic cyclohexane compounds

The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments.

Substituted heteroaryl derivatives

Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.

Spirocyclic cyclohexane compounds with analgesic activity

Substituted sulfonamide compounds corresponding to formula I pharmaceutical compositions comprising them, a process for preparing them, and the use of such compounds to treat or inhibit pain and other disorders or disease states.

Substituted sulfonamide compounds

Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.

Substituted amide compounds

Substituted imidazoline derivatives corresponding to Formula I: a method for producing them from substituted aldehyde compounds of Formula B: and the use of such imidazoline derivatives and aldehyde compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.

Substituted imidazoline compounds

Substituted oxazole derivatives corresponding to formula I: a method for producing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhoea, pruritus, alcohol and drug misuse, drug dependency, lethargy and/or anxiety.

Substituted oxazole compounds with analgesic activity

Substituted oxadiazole compounds corresponding to formula I: in which X denotes CH, CH, CH&#x2550;CH, CHCH, CHCH&#x2550;CH or CHCHCH; Rdenotes aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted; or a Calkyl group-linked aryl or heteroaryl group, in each case unsubstituted or mono- or polysubstituted; Rdenotes aryl or heteroaryl, in each case unsubstituted or mono- or polysubstituted; a Calkyl chain-attached aryl group, in each case unsubstituted or mono- or polysubstituted; and Rand Rindependently denote H; Calkyl, in each case saturated or unsaturated, branched or unbranched, wherein Rand Rdo not simultaneously mean H; or Rand Rtogether denote CHCHOCHCH, or (CH). The compounds have an affinity for the &#x3bc;-opioid receptor and may take the form of the racemate; enantiomers, diastereomers, mixtures of enantiomers or diastereomers, an individual enantiomer or diastereomer, a free base, or a salt with a physiologically acceptable acid.

Substituted oxadiazole compounds and their use as opioid receptor ligands

Growing community of inventors

Berlin, Germany

Heinz Graubaum