Sartorius Ag

Heraeus Instruments Gmbh

Heraeus Sepatech Gmbh

Sartorius

Heraeus Instruments Gmbh & Co. Kg

Heinz-Gerhard Kohn

Hans-Otto Nagels

Frank W Falkenberg

Werner Schulze

Matthias Eger

Christian Oldendorf

Christoph Berg

Michael Laubstein

Winfried Graf

Gunter Pradel

Eckart Kopowski

Rudiger Uhlendorf

Eduard Bierich

Rainer Kirchhoff

Helmut Kocher

Dieter Klausgrete

Paul Von Der Haar

Carsten Tischer

Jorg Peter Martens

Heinz Von Soosten

Hans-Dieter Lehmann

Holger Schmeisser

The invention relates to an electronic balance for use in an explosive environment. The invention calls for an intrinsically safe cable (1) which contains data lines in addition to the voltage supply lines. The data is serially transferred on the data lines. A first conversion unit is housed in the housing of a power pack which conversion unit receives the data arriving serially via the cable (1), converts it into parallel data and stores it so that it can be passed on in a parallel and asynchronous manner in the non-explosive area, that a second conversion unit is housed in the housing of the power pack which second conversion unit stores the data arriving in parallel manner from the non-explosive area, converts it into serial data and sends it serially via the cable (1) into the explosive area, and that the control unit (3) also contains at least a first conversion unit which receives the data arriving serially via the cable (1), converts it into parallel data, stores it and passes it on in parallel manner to the evaluation unit. The control unit contains at least one second conversion unit which stores the data arriving in parallel manner from the evaluation unit, converts it into serial data and sends it serially via the cable (1).

Electronic balance with data output for use in explosive areas

A laboratory centrifuge is known with a centrifuge housing which contains a motor and a rotor connected with the motor through a drive shaft, the motor being held in the motor housing which includes an upper end shield and a lower end shield, and with the motor having a rotor tank arranged above it which has a passage for the drive shaft on the motor side. In order to indicate, starting from here, a laboratory centrifuge which is economical to manufacture and simple to assemble, which can be cooled easily, if necessary, it is proposed that the rotor tank and the upper end shield be made as a single piece.

Laboratory centrifuge having a simplified design

A toploaded balance in accordance with the principle of the electromagnetic compensation of force with a divided upper guide rod (3, 3') and a divided lower guide rod (4, 4') which together as a parallel guide connect a load receiver (2) to a system carrier (1) fixed to the housing, which system carrier (1), load receiver (2) and guide rods (3, 3', 4, 4') form a one-piece base, with a translation lever (5) rotatably mounted by two flexible articulations (7) on the system carrier (1), with a coupling element (12) connected by flexible articulations on the one hand to the load receiver (2) and on the other hand to the short lever arm of the translation lever (5), with a magnet build, as viewed from above, into the free space between the parts of the guide rods (3, 3', 4, 4') and their extensions on the system-carrier side and with a coil fastened on the longer lever arm of the translation lever (5) and extending into the air gap of the magnet, the translation lever (5), the two flexible articulations (7) for mounting the translation lever (5) and the coupling element (12) with its flexible articulations (13, 14) are also a one-piece component of the base. In this manner errors by screwing the flexible articulations (7) and warping and non-reproducible return forces from other screw connections can be avoided.

Balance with scale on top

A lop loaded balance with a load receiver (1, 2, 3) connected by at least one upper (11) and at least one lower guide rod in the form of a parallel guide to a system carrier (4) fixed to the housing, which load receiver, guide rods and system carrier are manufactured from one piece. The system carrier (4, 5, 6, 7) is designed as a frame. The frame-like system carrier is completely surrounded by a second frame (14, 15, 16, 17) supported on the balance feet and that both frames are constructed in a one-piece manner and are connected to one another in such a manner that twistings of the one frame are transferred as little as possible onto the other frame.

Balance with scale on top with a one-piece parallel guide

A cell culture vessel which permits gentle but vigorous intermixing and suspending of the cell culture during rotation. The culture vessel features a cell mixing and suspending device combined with a gas exchange membrane such that ample gas exchange occurs without the need to feed oxygen to the cells. The cell mixing and suspending device comprises a baffle system having at least one, and preferably more than one, mixing elements integral with the gas exchange membrane. Movement of the culture vessel, such as for example by rolling, shaking or swirling, moves the mixing elements such that the cells which are to be cultivated are gently intermixed and stably suspended within the cell culture chamber. Pressure variations within the cell culture vessel are accommodated by pressure equalizing device. The pressure equalizing device preferably comprises pressure sheathing made of gas permeable material positioned to form at least a portion of the outer wall of the supply chamber. The pressure sheathing compresses to accommodate increased pressure within the supply chamber. Moreover, the gas permeable material permits additional gas exchange to occur through the supply chamber. Mixing of the nutrient medium is accomplished during movement of the cell culture vessel by way of the extending pressure finger.

Culture vessel for cell cultures

It is suggested for a balance with one or several weighing cells (1-4, 31) with a total of at least eight wire strain gauges (D.sub.1 -D.sub.4, S.sub.1 -S.sub.4), four of which (D.sub.1 -D.sub.4) are expanded under load and four (S.sub.1 -S.sub.4) compressed under load, in which the eight wire strain gauges are connected together circularly in series so as to form a single Wheatstone bridge which is supplied with voltage along a diagonal (12, 13) (vertical diagonal) and the output signal is taken off along the other diagonal (14, 15) (horizontal diagonal) that a signal is additionally tapped off along the upper horizontal chord (16, 17) and along the lower horizontal chord (18, 19). This makes possible a corner-load adjustment for the balance utilizing the additional signals.

Balance with one or several wire strain gauge weighing cells

Culture vessels for cell cultures having at least one cell culture chamber containing a cell culture mixture that is separated by a dialysis membrane from a nutrient medium in a nutrient supply chamber. Nutrients are transported through the dialysis membrane into the cell culture chamber and metabolic products are transported out of the cell culture chamber into the nutrient supply chamber. A gas exchange membrane that at least partly delimits the cell culture chamber and that is impermeable to liquids and to microorganisms that could contaminate the cell cultures is provided for feeding the gases required for cell culturing to the culture chamber and for discharging the gases generated during cell culturing. The cell culture chamber can advantageously be configured as a stand-alone module supporting both the dialysis membrane and the gas exchange membrane. The nutrient supply chamber can be configured as a cup-shaped module having an open end releasably interconnectable with the cell culture chamber module at the location of the dialysis membrane, via snap elements.

Modular culture vessel for cell cultures

Bioreactor

Culture vessels for cell cultures having at least one cell culture chamber containing a cell culture mixture that is separated by a dialysis membrane from a nutrient medium in a nutrient supply chamber. Nutrients are transported through the dialysis membrane into the cell culture chamber and metabolic products are transported out of the cell culture chamber into the nutrient supply chamber. To provide a culture vessel for generating cell cultures with a high cell density that is economical to manufacture and easy to handle and to reduce the danger of infections, a gas exchange membrane, that at least partly delimits the cell culture chamber and that is impermeable to liquids and to microorganisms that could contaminate the cell cultures is provided for feeding the gases required for cell culturing to the culture chamber and for discharging the gases generated during cell culturing.

To eliminate welds when forming connections from coupling joints of membrane filter structures having two external housing plates between which a membrane filter assembly (3, 4) is positioned, one (2) of the housing plates (1, 2) is formed with a bored or milled, essentially circular recess at each one of the locations where fluid connection couplings (6-9) are to be placed, the fluid connection couplings being formed by a plug element which is clamped in sealing engagement against a sealing bottom wall surface (13) of the respective recess. To provide absolute tightness, even of molecular substances such as bacteria, tissue elements, yeasts and the like, a sealing ring, preferably an O ring (15) is placed in a groove (14) formed in the sealing wall surface (13).

Membrane filter system

An improved method and apparatus for separating high-molecular-weight substances from cells suspended in liquid nutrient media, features continuous central monitoring and control of the process by a computer (22), and a way to combine the heretofore separate processes of first, separating media into solid and liquid components, and second, concentrating the proportion of high-molecular-weight components in the separated liquid. The media are conveyed by a first pump (3) to a centrifuge continuous flow rotor (2), which separates the solids from the liquid components and directs the latter to an intermediate reservoir (5), which sits on an electric scale (7) which is continuously monitored. From here they are fed to a filtration unit (9) in which the high-molecular-weight substances are separated and recycled through a feedback line (11), with the aid of a second pump (10), into the intermediate reservoir (5). The central computer and control unit (22) controls the centrifuge and pumps, monitors the scale (7) and pressure sensors (13), and adjusts the process parameters. An optical sensor (26) monitors the solids content at the centrifuge output (4).

Method and apparatus for separation of high-molecular-weight substances

A multilayer filter medium (6) is used for separating precipitates containing cholesterol from blood plasma which consists of at least one open filter medium (7) which adsorbs precipitate and of a microporous membrane (9) which controls the pressure conditions in the filter element, whereby the layer (7) which specifically adsorbs the precipitate is hydrophobic and the microporous membrane (9) is hydrophilic. In addition, a positively charged adsorption medium (9) is provided on the side of the microporous membrane (8) facing away from the hydrophobic adsorption medium (7). In this manner, a large adsorption area is created and kept accessible for the precipitates and for heparin.

Filter unit for separating precipitates containing cholesterol

In a filter for filtering human blood, especially in an extracorporeal circulatory system, with a blood inlet, a blood outlet and a vertically directed, hollow, cylindrical filter element located between them and consisting of a filter, and in which the hollow, cylindrical filter element seals housing chambers located in the filter housing between the blood inlet and the blood outlet in such a manner from each other by means of its front surfaces that the blood can only flow through the filter element, whereby the blood inlet is located in the center of the housing and of the hollow, cylindrical filter element and a gas outlet is located at the highest point of the housing, the blood inlet runs axially through the hollow cylinder of the filter element as a central ascending tube and divides it cross section into a smaller ascending pipe section and into a settling chamber section for the blood which is several times larger. The settling chamber section empties in its extended axis into a cylindrical gas separation chamber which comprises a closable gas outlet. The blood outlet is provided in the area of the lowest active filter surface of the filter element as a horizontally projecting connection piece which communicates only with an annular space surrounding the outside of the filter element. The annular space is located in the area of the upper active filter surface of the filter element and comprises its own closable gas outlet at the highest point of an annular space, which runs preferably obliquely to the vertical filter axis.

Growing community of inventors

Dransfeld, Germany

Heinz-Gerhard Kohn