Nycomed Austria Gmbh

Cl Pharma Aktiengesellschaft

Heinz Blaschke

Harald Fellier

Peter Kremminger

Franz Rovenszky

Michael Hartmann

Dagmar Stimmeder

Thomas Christoph

Rita Enzenhofer

Jorg Berg

Heimo Stroissnig

The present application relates to compounds of formula (I) wherein A represents oxygen, sulfur or &mdash;NH&mdash;, m is 0-2, and R,, R,, R,, R,and R,have the meanings given in the specification, to a process for their preparation, as well as to their use in the inhibition of cyclooxygenase II.

Substituted derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II

Derivatives of benzosulphonamides as inhibitors of the enzyme

The invention relates to new piperazinylalkyl-3(2H)-pyridazinones of the formula ##STR1## in which the radicals R.sub.1 represents hydrogen, phenyl, benzyl, or (C.sub.1 -C.sub.6)-alkyl which is unsubstituted or substituted one or more times by hydroxyl, piperidine, morpholine or by a group NR.sub.4 R.sub.5 in which R.sub.4 and R.sub.5 can be identical or different and which represent hydrogen, methyl or ethyl,

Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents

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Linz, Austria

Heinz Blaschke