Forschungsverbund Berlin E.v.

Ludwig-Maximilians-Universitat München

Ludwig-Mavimilians-Universität München

Ludwig-Maximilians-Universität

Heinrich Leonhardt

Christian Hackenberger

Dominik Schumacher

Jonas Helma-Smets

Jonas Helma

Andreas Stengl

Marc André Kasper

Maria Glanz

Tom Sauer

Ulrich Rothbauer

Serge Muyldermans

Tina Romer

Kourosh Zolghadr

Katrin Schmidthals

Marc-André Kasper

Marcus Gerlach

Alice Leonie Baumann

Stephen Byrne

Tina Stoscheck

Oliver Mortusewicz

Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene-or alkyne-phosohonothiolates and -phosphonates comprises the step of: reacting a compound of formula (I) with a thiol-containing molecule of formula (II) wherein represents an amino acid, a peptide, a protein, an antibody, a nucleotide, an oligonucleotide, a saccharide, a polysaccharide, a polymer, an optionally substituted C-C-alkyl, an optionally substituted phenyl, or an optionally substituted aromatic 5- or 6-membered heterocyclic system; resulting in a compound of formula (III).

Chemoselective thiol-conjugation with alkene or alkyne-phosphonothiolates and -phosphonates

Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of

Chemoselective thiol-conjugation with alkene or alkyne-phosphonamidates

The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.

Means and methods for site-specific functionalization of polypeptides

The present invention provides means and methods for functionalizing a polypeptide of interest at its C-terminus with an amino acid derivative.

Unusual substrates of tubulin tyrosine ligase

Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII). 

The present invention relates to a nucleic acid molecule encoding a polypeptide specifically binding to proliferating cell nuclear antigen (PCNA). The present invention also relates to a vector comprising the nucleic acid molecule of the invention, a host cell comprising the nucleic acid molecule of or the vector of the invention and a method of detecting the amount and/or location of PCNA in living cells, a method of screening for compounds having an effect on the cell cycle.

Detection and visualization of the cell cycle in living cells

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Munich, Germany

Heinrich Leonhardt