Bayer Aktiengesellschaft

Miles Inc.

Heinrich F Moeschler

Klaus Schaller

Richard F Hector

Manfred Plempel

Wolfgang Pfluger

Detlef Wendisch

Klaus Sasse

Peter M Lange

Gerhard Zoebelein

Christian Golker

Otto Telle

Manfred Blempel

Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.

Antimycotic compositions of nikkomycin compounds and azole antimycotics

The nikkomycin compound possessing antimycotic activity and having the following structure: ##STR1##

Nikkomycin derivatives

Nikkomycin derivatives have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.

A method of treating a mammal infected with a dimorphic, highly chitinous fungi, the method comprising administering to the mammal therapeutically effective amounts of a nikkomycin derivative having the following structure: ##STR1##

Method for treating fungal infections with nikkomycin derivatives

Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a snyergistic anti-fungal effect.

Antimycotic compositions of nikkomycin compounds and azole antimycotica

Nikkomycin derivatives, antimycotic compositions of nikkomycin

Annonin, a substantially pure insecticidally active compound obtained by extracting comminuted Annona squamosa parts to remove the petroleum ether solubles, then optionally extracting with alcohol to dissolve the desired material, then extracting either the petroleum ether-residue or the alcohol extract with an aliphatic halogenohydrocarbon, an aliphatic ether and/or an ester, and discarding the residue, and evaporating off the solvent. It has the 1R spectrum shown in the drawing.

Pure annonin and a process for the preparation thereof

Arthropodicidally and fungicidally active heavy metal salts of nikkomicin are produced by reacting nikkomicin with a water-soluble heavy metal salt in an aqueous medium.

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Leverkusen, Germany

Heinrich F Moeschler