Gambro Lundia Ab

Heinrich Behr

Bernd Krause

Reinhold J Buck

Markus Hornung

Carina Zweigart

Arnd Wochner

Markus Storr

Werner Beck

Joachim Loercher

Philipp Herbst

Adriana Boschetti-De-Fierro

Manuel Voigt

Ralf Flieg

Wolfgang Freudemann

Martin Rempfer

Evelyn Grossmann

Cornelia Winz

Carl-Philipp Scheuermann

Markus Loeffler

Manuela Klotz

The present disclosure relates to a spinneret for producing hollow fiber membranes in a phase inversion process.

Spinneret

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Hemodialyzer for blood purification

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

Membrane for blood purification

Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, including improved sieving characteristics, providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.

Membranes having improved performance

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Hechingen, Germany

Heinrich Behr