Godecke Aktiengesellschaft

Heinrich Bahrmann

Gerhard Satzinger

Manfred F Herrmann

Volker Ganser

Wolfgang Steinbrecher

Johannes Hartenstein

Edgar Fritschi

Wolfgang Dieter Herrmann

Bernd Wagner

The present invention provides 5,6;8,9-tetrahydro-7H-dibenz(d,f)azonine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are hydrogen or halogen atoms or lower alkyl or alkoxy radicals, R.sup.3 is a hydrogen atom or a lower alkyl radical, R.sup.4 is a hydrogen atom or a lower alkyl or alkanoyl radical and n is 1 or 2; and the pharmaceutically acceptable salts thereof formed with inorganic and organic acids; but excluding 6-benzyl-2,12-dimethoxy-1-hydroxy-7-methyl-5,6;8,9-tetrahydro-7H-dibenz(d, f)azonine in which case R.sup.1, R.sup.2 and R.sup.4 are hydrogen, n is 1 and R.sup.3 is methyl. The lower alkyl, alkanoyl and alkoxy radicals are straight chained or branched radicals containing 1 to 5 carbon atoms. The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.

5,6;8,9-Tetrahydro-7H-dibenz(d,f)azonines

Novel azocine derivatives and a method for their preparation are disclosed. The compounds display analgesic effects in mammals.

Azocine analgesics and method for their preparation

The invention discloses (+)-(3-methyl-4-oxo-5N-piperidinothiazolidin-2-ylidene)acetic acid esters and a process for their preparation. The process provides the dextrorotatory isomers substantially free from the corresponding levorotatory isomers. Antihypertensive pharmaceutical compositions comprising the dextrorotatory esters and methods for using said compositions are also disclosed.

(+)-(3-Methyl-4-oxo-5N-piperidinothiazolidin-2-ylidene)acetic acid

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Kirchzarten, Germany

Heinrich Bahrmann