Boehringer Mannheim Gmbh

Roche Diabetes Care, Inc.

Roche Diagnostics Operations, Inc.

Hitachi-high-technologies Corporation

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Heino Eikmeier

Klaus-Dieter Sacherer

Hans-Juergen Kuhr

Wilfried Schmid

Joerg Schreiber

Hans-Peter Haar

Carina Horn

Anselm Rothe

Joachim Hoenes

Stefan Weinert

Ulrich Porsch

Steven Bousamra

Juergen Rasch-Menges

John F Price

Karl Werner

Helmut Freitag

Ewald Rieger

P Douglas Walling

Birgit Kraeling

Isao Yamazaki

Stephan Sattler

Hitoshi Tokieda

Masaharu Nishida

Wolfgang-Reinhold Knappe

Masaaki Hanawa

Christoph Eisenhardt

Hans-Erich Wilk

Masaki Shiba

Dietmar Kappelhoff

Wolfgang Weckerle

Christian Freitag

Christoph Möllers

Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.

Portable diagnostic measurement device for determining analytical parameter of body fluid

Embodiments of a testing method for diabetics to optimize their administered insulin dosage comprise collecting sampling sets of biomarker data, each sampling set comprising a sufficient plurality of non-adverse sampling instances and each sampling instance comprising an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when biomarker sampling parameters fall within the target biomarker range.

Systems and methods for optimizing insulin dosage

Portable diagnostic measurement device for determining at least one analytical parameter of a body fluid

Embodiments of a testing method suitable for diabetic persons to optimize their administered insulin dosage comprise collecting one or more sampling sets of biomarker data, wherein each sampling set comprises a sufficient plurality of non-adverse sampling instances and wherein each sampling instance comprises an acceptable biomarker reading at a single point in time recorded upon compliance with adherence criteria, determining a biomarker sampling parameter from each sampling set, comparing the biomarker sampling parameter to a target biomarker range, calculating an insulin adjustment parameter associated with the biomarker sampling parameter if the biomarker sampling parameter falls outside the target biomarker range, adjusting the insulin dosage by the insulin adjustment parameter if the biomarker sampling parameter falls outside the target biomarker range and if the insulin dosage does not exceed maximum dosage, and exiting the testing method if the adjusted insulin dosage is optimized. The insulin dosage is optimized when one or more biomarker sampling parameters fall within a target biomarker range.

Storage containers for storing at least one diagnostic test element including an enzyme and a stabilized coenzyme are disclosed. In addition, diagnostic products which include diagnostic test elements including an enzyme and a stabilized coenzyme, as well as analytical measuring devices which include such storage containers or diagnostic products, are also disclosed. Other aspects include, but are not limited to, unique methods, techniques, products, systems and devices involving test elements which include an enzyme and a stabilized coenzyme.

Simplified storage of at least one test element including a dry reagent layer having an enzyme and a stabilized coenzyme

A system is provided for measuring an analyte concentration in a body fluid sample, comprising at least one cartridge that contains consumables for multiple measurements, a data carrier affixed to the cartridge that contains calibration information for the consumables, a hand-held device including a reading facility for receiving a cartridge of this type and for reading its data carrier, a measuring facility for measuring the result of a detection reaction, and a processor for controlling the measuring facility and for analysis of a measuring signal. At least one replaceable data storage unit is further provided in which supplementary data is stored. The data storage unit functions in combination with calibration information from the data carrier and is used by the processor to determine whether the consumables of the inserted cartridge renders a reliable measurement of analyte concentration.

System for measuring an analyte concentration of a body fluid sample

An automatic analyzer is disclosed that dispenses a sample and a reagent into each of a plurality of reaction vessels to allow them to react with each other, and that measures the liquid formed as a result of the reaction. This automatic analyzer includes a first reagent storage case for storing the reagent to be used for the reaction, a second reagent storage case for storing the reagent for supplemental purpose, and a reagent conveying unit for conveying the reagent from the second reagent storage case to the first reagent storage case.

Automatic analyzer

A systems for test elements used for clinical chemical analyses has several test elements, each of which is individually sealed to be impermeable to water vapor. The method provides for the removal of test elements and protects the test elements contained in it against effects from the outside.

Storage system for test elements

The system has several test elements, each of which is individually sealed to be impermeable to water vapor. The system storing test elements facilitates removal of test elements and protects the test elements contained in it against effects from the outside.

A system for analyzing sample liquids using dry reagents which is particularly suitable for the determination of clinical parameters. The system includes an analysis instrument containing the individually sealed test elements to carry out an analytical test. Shape and nature of the test elements were designed to match the analysis system. The system is particularly suitable for analyses where the available test elements exhibit a low storage stability when brought into contact with the environment.

Test elements in sealed chambers for analyzing compounds contained in

The invention is within the field of packaging and storing of test elements that are usually sensitive towards atmospheric humidity or water vapor. The invention concerns a system for the storage of test elements for the analysis of sample liquids in which two or more test elements are present in a storage container which can be sealed water-vapor tight and contains a desiccant inside.

System for the storage of test elements

System for analyzing compounds contained in liquid samples

The present invention concerns compounds having the general formula I ##STR1## in which R.sup.1 denotes hydrogen or hydroxy,

Diphenylmethane derivatives, process for their production and their use

The present invention provides a diagnostic agent for the enzymatic determination of cholesterol, wherein, besides the necessary enzymes, it contains a scleroprotein or a scleroprotein hydrolysate; said invention also provides a process for the production of a reagent film for the detection of cholesterol, as well as a test strip for the detection of cholesterol; and said invention is also concerned with the use of scleroproteins and scleroprotein hydrolysates for increasing the enzyme stability in diagnostic agents for the detection of cholesterol and for increasing the temperature-independence of the detection of cholesterol with diagnostic agents.

Scleroprotein and scleroprotein hydrolysate containing agent for

Test carrier for analyzing a sample fluid with several test layers which form a sample fluid transport path and contain a reagent system which reacts with the sample fluid to produce a detectable signal. The test carrier includes a reservoir layer of absorbent material, a detection layer arranged in the fluid transport path downstream the reservoir layer, in which a detectable signal is formed, and a separating layer arranged between the reservoir layer and the detection layer. The separating layer makes a two-step process possible. Fluid contact between the reservoir layer and the detection layer arises only with pressure loading of the layer assembly of the reservoir layer, separating layer and detection layer. A more uniform optical detection signal, and consequently better accuracy, can be achieved because the separating layer is made up of a hydrophilic material, wich is in the form of a lattice-shaped structure, in which the mean width of the lattice openings is more than 0.05 mm, and the threads from which the lattice-shaped structure is formed are multi-filament.

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Lorsch, Germany

Heino Eikmeier