Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Heiko Weyd

Peter Krammer

Fatmire Bujupi

Kevin Bode

Peter H Krammer

Alexandra Kurz

Björn Linke

Bjorn Linke

The present invention relates to an annexin-coated particle, comprising a negatively charged phospholipid and an annexin non-covalently coupled thereto. The present invention further relates to a composition comprising an annexin-coated particle. Furthermore, the present invention relates to a product for use in a method of preventing or treating a disease selected from a chronic inflammatory disease, an autoimmune disease, an allergy, and a cancer, said product comprising an annexin-coated particle, and/or a composition. The present invention further relates to a method of preparing an annexin-coated particle.

Annexin-coated particles

The present disclosure provides immunogenic compositions, such as vaccines, including DNA vaccines, and uses thereof, e.g., which include an annexin core domain to mediate efficient antigen delivery and antigen presentation in order to induce an antigen-specific immune response and/or to treat or prevent infectious diseases and/or cancer.

Core domain of annexins and uses thereof in antigen delivery and vaccination

Growing community of inventors

Mannheim, Germany

Heiko Weyd