Bayer Oy

Bayer Schering Pharma Ag

Upm-Kymmene Corporation

Schering Oy

Heikki Lyytikäinen

Ilkka Jutila

Ulla Calvo Alonso

Harri Jukarainen

Taina Tjäder

David Whitaker

Pirjo Kortesuo

Hannu Nikander

Pirjo Inki

Eeva Lukkari-Lax

Joachim Moede

Juha Lehtinen

Pirjo Sallinen

Andrew Macleod

Michael Noble

Marjo Ali-Äijälä

Michael Nobel

Taina Träder

Ulrike Fuhrmann

Bernhard Lindenthal

Jyrki Pihlaja

Manja Ahola

Ina Gröticke

Bernd Duesterberg

Satu Kleemola

Tero Parkatti

Tuula Valo

Christian Wamprecht

Antti Laukkanen

Wolfgang Kaufhold

Jari Riski

Joonas Mikkonen

Christine Talling

Timo Laaksonen

Faisal Shafiq

Pentti Järvelä

Petri Laakso

Esa Hallinen

Svante Holmberg

Jouni Hirvonen

Ruzica Kolakovic

Ilkka Kivi

Petri Perälä

Antti Töyrylä

Juuso Pohjola

Jorma Roine

Saara Ruotsalainen

Esko Moisala

Taina TJÄDER

Leena Peltonen

Prijo Kortesuo

According to an aspect of the present invention, there is provided an apparatus for ultrasonic welding of a removal thread () of an intrauterine system (). The apparatus comprises a welding jig () comprising a welding groove (), the welding groove having a length Lg, a width Wg and a depth Dg and a bottom () with concave shape. The apparatus further comprises a sonotrode () having a length Ls that is 150-220% of Lg, a width Ws of a welding tip () of the sonotrode that is 80-98% of Wg and a depth Ds. Further, the welding tip of the sonotrode has a concave shape.

Ultrasound thread welding

An inserter for an intrauterine system can include a handle having an opening, a slider arranged in the opening, a plunger attached to the handle, an insertion tube attached to the slider and arranged around the plunger, and a lock adapted to reversibly lock at least one removal string of the intrauterine system. The lock can include a main part with an opening, the main part being rotatably mounted on a shaft or axle, an extension of the main part, and a counterpart. The removal string passes through the opening of the main part and is immobilized between the main part and the counterpart when the lock is in a locking position. The slider is configured to press against the extension of the main part and turn the main part around the shaft or axle to release the removal string as the slider is moved backwards.

Inserter

The invention relates to an inserter for an intrauterine system, including a handle () having a longitudinal opening () at its first end, the opening () having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end () and a second end (), a moveable slider () arranged in the longitudinal opening () and having a first end () and a second end (), a plunger () attached to the handle (), an insertion tube () arranged around the plunger () having a first end and a second end, with its second end attached to the slider (). The inserter further includes a lock that reversibly locks the intrauterine system in relation to the plunger () via a removal string of the intrauterine system, the lock being controllable by the slider () and/or the insertion tube ().

The present invention relates to an inserter for an intrauterine system comprising a handle (), and an insertion tube () having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube () comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system () comprises a therapeutic component () and a continuous, closed frame (), the therapeutic component () being connected to the frame () at least one point, and therapeutic component () of the intrauterine system () is at least mainly arranged inside the first end of the insertion tube () and the frame () of the intrauterine system () is at least mainly arranged outside the first end of the insertion tube ().

The invention relates to an inserter for an intrauterine system, including a handle () having a longitudinal opening () at its first end, the opening () having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end () and a second end (), a moveable slider () arranged in the longitudinal opening () and having a first end () and a second end (), a plunger () attached to the handle (), an insertion tube () arranged around the plunger () having a first end and a second end, with its second end attached to the slider (). The inserter further includes a lock that reversibly locks locking the intrauterine system in relation to the plunger () via a removal string of the intrauterine system, the lock being controllable by the slider () and/or the insertion tube ().

The present invention relates to an inserter for an intrauterine system, comprising a handle () having a longitudinal opening () at its first end, said opening () having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end () and a second end (), a movable slider () arranged in said longitudinal opening () and having a first end () and a second end (), a plunger () attached to the handle () and having a longitudinal axis, and an insertion tube () having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (), the insertion tube () being, along said longitudinal axis, movably arranged around the plunger (). The invention is characterised in that it further comprises a flange () arranged on the insertion tube () at its first end, and means for locking the slider () into a position showing the correct insertion depth for the intrauterine system, said means being adjustable with respect to the opening () of the handle.

A drug delivery system for sustained delivery of bioactive agents, the system includes a matrix including nanofibrillated cellulose derived from plant based material and at least one bioactive agent, and at least one support selected from synthetic polymers, bio compounds and natural polymers. Also, methods for the manufacture of the system and methods of using it.

Drug delivery system for sustained delivery of bioactive agents

The invention relates to a method for producing a drug delivery device, which has a body comprising a siloxane-based elastomer and at least one active agent. The method comprises applying adhesive material, which comprises non-cured siloxane based elastomer, into a contact with the body and curing the said adhesive material by subjecting it to radiation energy from a laser source. The invention relates also to a drug delivery device manufactured according to the method.

Method for manufacturing a drug delivery device and a drug delivery device manufactured according to the method

The invention relates to an inserter for an intrauterine system, comprising a handle () having a longitudinal opening () at its first end, said opening () having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end () and a second end (), a movable slider () arranged in said longitudinal opening () and having a first end () and a second end (), a plunger () attached to the handle (), an insertion tube () arranged around the plunger () having a first end and a second end, with its second end attached to the slider (), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunger () via a removal string of the intrauterine system, said locking means being controllable by the slider () and/or the insertion tube ().

The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.

Intrauterine delivery system for contraception

The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.

Drug delivery system

An inserter for an intrauterine system includes a handle. The handle has a longitudinal opening at its first end, the opening having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end and a second end, a movable slider arranged in the longitudinal opening and having a first end and a second end. The inserter also includes a movable plunger and an insertion tube arranged around the plunger having a first end and a second end, with its second end attached to the slider. The handle further includes a lock for reversibly locking the intrauterine system in relation to the plunger via a removal string of the intrauterine system, the lock being attached to the plunger and being controllable at least by a part or an extension of the slider and/or of the insertion tube or of the handle.

Inserter for an intrauterine system

Growing community of inventors

Naantali, Finland

Heikki Lyytikäinen