Wallac Oy

Other

Wallace Oy

Heikki K Kouru

Mikko Sairanen

Kenneth C Rundt

Teemu Korpimäki

Pertti Hurskainen

Tarja Ahola

Tapio Yrjonen

Timo E Oikari

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNFR1, PIGF2, Activin A, uE3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

Method for determining the risk of preterm birth

A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

System and method for determining risk of diabetes based on biochemical marker analysis

The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.

Method for determining risk of pre-eclampsia

The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCGbeta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

A method for the evaluation of sample activities in multidetector liquid scintillation counters. All prepared quench curve standards are measured only in one reference detector in order to establish the relationship between the quench levels and the counting efficiencies. In addition, only two of the standards, preferably those with lowest and highest level of quench, are measured in every detector in order to establish the relationship of the quench levels between the reference detector and any other detector and in order to establish the relationship of the counting efficiencies between the reference detector and any other detector. The activities of unknown samples are evaluated by utilizing the predetermined relationships.

Method for evaluating sample activities in a multidetector liquid

The object of the invention is a method for the evaluation of sample activities in multidetector liquid scintillation counters. According to the invention the memory of said apparatus is provided with a theoretically derived model for each isotope between the counting efficiencies and the quench levels. In addition at least one standard is measured in each detector in order to establish relationships between said theoretical model and each detector. The activities of an unknown sample is evaluated by utilizing said theoretical model and said relationship.

Apparatus and a method for measuring the activity of radioactive samples

Method and apparatus for producing a quench calibration function for a

In a liquid scintillation counter the light output from a liquid scintillation sample containing radioactive isotopes of unknown activity is measured by means of a detector. A pulse height analyzer having discriminators that are combined to define pulse height windows, is connected to the detector for measuring and temporarily storing count rates for each of the windows. Moreover, there are means for determining a value for the quench level of the sample. According to the invention the number of pulse height windows is at least N+1, when the number of isotopes is N,N being .gtoreq.2. There are memory means for storing for each of said windows representations of counting intensities determined by measuring calibration samples of each isotope at different levels of quench. Moreover, there are means for extracting from said stored representations a counting intensity for each window and each isotope on the basis of said determined quench level value, and means for determining for each isotope a factor by which the extracted counting intensities are to be multiplied in order to fit the sum of the extracted counting intensities to the count rates measured for the sample in each window, each said factor being directly related to the amount of each isotope in the sample.

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Turku, Finland

Heikki K Kouru