D.e. Shaw Research, LLC

Relay Therapeutics, Inc.

Heike Schoenherr

Fabrizio Giordanetto

Alexander M Taylor

Demetri T Moustakas

Brandi M Hudson

Thomas H McLean

Paul Maragakis

Jack Benjamin Greisman

Alessandro Boezio

Mary M Mader

Bakary-Barry Touré

Pelin Ayaz

Ravi Kurukulasuriya

Dina A Sharon

The present disclosure relates to novel compounds of formula I-1, and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with FGFR signaling with the compounds and compositions of the disclosure.

FGFR inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors and methods of use thereof

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of FGFR enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with FGFR signaling with the compounds and compositions of the disclosure.

Growing community of inventors

Cambridge, MA, United States of America

Heike Schoenherr