Other

King's College London

Kings College

Deutsches Wollforschuncsinstitut an Der Rwth Aachen

Deutsches Wollforschungsinstitut

Heike Eckey

Peter Henri Sonksen

Dietrich Brandenburg

Fariba Shojaee-Moradi

Achim Schuttler

Richard Henry Jones

Henry R Jones

Erik Sundermann

The invention provides an analogue of a pharmaceutical active whose molecular weight is less than 25,000 Daltons, the analogue comprising a pharmaceutical active whose molecular weight is less than 25,000 Daltons covalently linked to a pendant molecular group wherein as a result of the administration of the composition to the human or animal body an active complex having a molecular weight of 25,000 Daltons or greater is present in the human or animal circulatory system. The analogue is hepatoselective when administered to the circulatory system. Preferably the analogue is an insulin analogue comprising an insulin or functional equivalent thereof covalently linked to the pendant molecular group wherein the active complex is an insulin complex. Such an insulin analogue may be used in a method of insulin replacement therapy.

Pharmaceutical active conjugates

Hepatoselective pharmaceutical actives

Growing community of inventors

Holzminden-Silberborn, Germany

Heike Eckey