Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Heike Boehm

Joachim P Spatz

Christian Lingenfelder

Sabine Laschat

Valentin Hagel

Markus Manfred Mateescu

Seraphine Valeska Wegner

Fania Geiger

Tabea Mundinger

Michael Thaller

Isabell Nuss

The present invention relates to an ocular device for regulating intraocular fluid pressure comprising or consisting of a tubular body wherein the inner surface of the tubular body or the inner and outer surface is/are coated with covalently immobilized hyaluronic acid (HA). In more specific embodiments, the tubular body comprises or consists of a biocompatible material selected from the group comprising a biocompatible metal such as titanium, ceramics, glass, polymers and composites thereof, and the immobilized hyaluronic acid molecules are linked with further HA molecules to form a HA hydrogel. The ocular device is a stent free from mechanical valves or other mechanical means for actively regulating the flow of intraocular fluid.

Intraocular device and method for preparing the same

The present invention relates to novel cross-linkers for hydrogels, in particular for hyaluronan hydrogels, corresponding hydrogels including said cross-linkers and various applications thereof. The cross linker of the invention is a bi- or multifunctional cross-linker comprising or consisting of an aromatic or heteroaromatic ring system with 3-6 C atoms which is coupled via functional groups on at least 2 ring positions with at least 2 terminal groups capable to form a covalent bond with thiol or amino groups, in particular with thiol groups in a thiol-en reaction. The cross-linker may be charged or uncharged. In a specific embodiment, the terminal groups are coupled to carboxy groups of the aromatic or heteroaromatic ring system via an ester or amide bond. More specifically, the cross-linker of the invention is a derivative of pyridine-3,5-dicarboxylic acid or a corresponding pyridinium salt thereof wherein 2 terminal groups are coupled to the carboxy groups of the pyridine or pyridinium core via an ester or amide bond. In a preferred embodiment, the cross-linker if N,N-bis(2-acrylamidoethyl) pyridine-3,5-dicarboxamide or a 3,5-bis((2-acryl-amidoethyl) carbamoyl)-1-methylpyridin-1-ium-halogenide.

Cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof

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Weinheim, Germany

Heike Boehm