Novartis Ag

Alcon, Inc.

Heike Arndt

Bernhard Seiferling

Harald Bothe

Yasuo Matsuzawa

Katharina Schmid

Katharina Nikolaus

Stephan Wittmar

Thomas Wasse

The invention is generally related to soft contact lenses which comprise a polyvinylalcohol-based hydrogel lens body and a durable lubricious coating thereon which are covalently attached to the polyvinylalcohol-based hydrogel lens body through 6-membered acetal rings and to a method for producing the same.

Soft contact lenses with a lubricious coating covalently-attached thereon

The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of &#x2266;5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mof &#x3e;5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.

Process for the coating of biomedical articles

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Mömlingen, Germany

Heike Arndt