Cybio Ag

Scienova Gmbh

Heidrun Rhode

Stefan Kreusch

Edith Zimmermann

Helga Endmann

Barbara Horn, Legal Representative

Günther Sammler

Gerhard Cumme

Michael Händel

Margarete Schulze

A device is provided by means of which biomolecules in samples in a volume range from &#x3c;1 &#x3bc;l to 500 &#x3bc;l can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane.

Device for receiving, treating, and storing small volume samples

A method for characterizing highly parallelized liquid handling technology using microplates and test kit for carrying out the method. Possibilities for characterizing a multi-channel or many-channel handling technology are known in principle. However, especially with regard to more highly parallelized devices and very small volumes, particularly under conditions corresponding to the actual application conditions, these possibilities were relatively expensive and presented problems especially with respect to the accuracy of evaluation and with respect to correctness and precision. The present method enables a more economical and very exact characterization for applications of this kind. According to the invention, a) a mean sample volume or mean reagent volume is determined by gravimetry from the totality of sample liquid or reagent liquid of all individual channels of the liquid handling technology; b) a normalized mean optical intensity is formed from optical measurement signals of all sample volumes or reagent volumes, each of which is mixed with a diluent; c) the volume accuracy of every individual channel of the liquid handling technology with respect to the mean sample volume or mean reagent volume is determined from the intensity deviation of the normalized optical measurement signal of the individual channel in relation to the normalized mean optical intensity. Further, a test kit is provided for advantageous implementation of the method. The invention is used wherever highly parallelized liquid handling technology is to be characterized with respect to accuracy and precision, particularly when the handled volumes lie within the &#x3bc;l range or sub-&#x3bc;l range and characterization is to be carried out under conditions approximating the real operating conditions.

Method for characterizing a highly parallelized liquid handling technique using microplates and test kit for carrying out the method

Growing community of inventors

Hainichen, Germany

Heidrun Rhode