Bristol-myers Squibb Compnay

Heidi L Perez

Robert Michael Borzilleri

Gretchen M Schroeder

Donna Wei

Erik M Stang

Kyoung S Kim

Andrew J Tebben

Yong Zhang

Liping Zhang

Sanjeev Gangwar

James A Johnson

Andrew Forrest Donnell

David K Williams

Zhen-Wei Cai

Heng Cheng

Tram N Huynh

Robert J Schmidt

Sunita V Dewnani

The invention generally relates to compounds of formula I which are antagonists of CXCR4. The invention includes pharmaceutically acceptable salts, compositions, methods of making the compounds of formula I, and methods of using the compounds of formula I for therapeutic indications. 

CXCR4 receptor antagonists

Tubulysin analogs of the formula (I) where R, RR, R, R, R, R, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Tubulysin analogs and methods of making and use

Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses

There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention. 

IAP antagonists

There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds. 

Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds. 

Substituted sulfonamides useful as antiapoptotic Bcl inhibitors

There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

Growing community of inventors

Ewing, NJ, United States of America

Heidi L Perez