Vanderbilt University

Heidi E Hamm

Craig William Lindsley

Shaun R Stauffer

Kayla J Temple

Matthew T Duvernay

James E Crowe, Jr

Eva M Harth

Bryan Voss

Sharon K Hamilton

Summer E Young

Kui Huang

Wandong Wen

Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating diseases related to thrombotic disorders by administration of the composition.

Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (PAR-4) antagonists

Embodiments of the invention include substituted indole compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating diseases related to thrombotic disorders by administration of the composition.

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists

In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: and at least one guanidinium residue, wherein m is zero or a positive integer. Also disclosed are methods of preparing the disclosed compounds. Also disclosed are methods of intracellular delivery comprising administering the disclosed compounds and compositions to a subject. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds or compositions of the invention and a pharmaceutically acceptable carrier. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Dendritic molecular intracellular transporters and methods of making and using same

Growing community of inventors

Nashville, TN, United States of America

Heidi E Hamm