University of Florida Research Foundation Inc

University of Central Florida Research Foundation Inc

Heesun Yang

Swadeshmukul Santra

Paul Howard Holloway

Glenn A Walter

Robert A Mericle

Subir Kumar Sabui

The present invention relates to fluorescent, radio-opaque and magnetic quantum nanoparticles, useful as multifunctional contrast agents or probes for in vivo bioimaging, and methods of their use. The invention provides for multifaceted bioimaging (e.g., intra-arterial pre-operative brain mapping and broad based in vivo diagnostic imaging), including imaging of various cell types, such as stem cells.

Nanoparticles and their use for multifunctional bioimaging

A partially passivating core shell particle includes a luminescent nanocrystal core, and a partially passivating semiconducting core shell on a surface of the nanocrystal. The shell allows selected analytes to alter a luminescent response of the core shell particle. A quantum dot-based sensing system includes at least one partially passivating core shell particle, a light source for irradiating the partially passivating core shell particle, and a light detector for receiving emissions from the particle, wherein emissions from the core shell particle change in response to the presence of at least one analyte.

Partially passivated quantum dots, process for making, and sensors therefrom

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Gainesville, FL, United States of America

Heesun Yang