Lysentech Co., Ltd.

Hankuk University of Foreign Studies Research Business Foundation

Arkgen Bioscions Co., Ltd

Lysentech

Heejoon Myung

Min Soo Kim

Jaeyeon Jang

Yoonjung Hwang

Jione Pyeon

Hye-Won Hong

Young Deuk Kim

Yunyeol Jo

Provided are a novel polypeptide having endolysin activity, a fusion protein comprising the polypeptide and an antibiotic active protein, and an antibiotic use against a gram-negative pathogen of the polypeptide and/or fusion protein and/or a use for prevention and/or treatment of gram-negative pathogen infection and/or disease or symptoms related to gram negative pathogen infection.

Polypeptides and antibiotics against gram-negative bacterium comprising the same

Provided is a method and composition using ROS to increase the production of bacteriophage. According to the subject matter, a production amount of bacteriophage is increased several times in the presence of the sublethal concentration of ROS for host bacteria. Therefore, the method and composition of the subject matter can be useful for producing bacteriophage, which is used as an alternative to antibiotics that cause a serious resistance problem.

Composition and method for increasing production of bacteriophage using reactive oxygen species

Provided are a novel polypeptide, a fusion polypeptide comprising the polypeptide, and a use thereof as an antibiotic. More specifically, provided are a novel polypeptide derived from a bacteriophage, a novel fusion polypeptide comprising cecropin A, and an antibiotic against Gram-negative bacteria comprising the polypeptide and/or the fusion polypeptide.

Polypeptide, fusion polypeptide, and antibiotic against gram-negative bacteria comprising same

Provided is an oncolytic recombinant bacteriophage T7 expressing a cytokine in eukaryotic cells and displaying on its capsid a tumor specific homing peptide, thus inducing direct lysis of target tumor cells and immunological response to the phage leading to the effective anticancer effect. The phage naturally infecting bacteria, not human beings, provides a great advantage for gene manipulation and production for the development of anticancer agents.

Oncolytic T7 bacteriophage having cytokine gene and displaying homing peptide on capsid and its use for treating melanoma

Growing community of inventors

Yongin-si, South Korea

Heejoon Myung