Sorrento Therapeutics, Inc.

Heehyoung Lee

Yanwen Fu

Heyue Zhou

Tong Zhu

Gunnar F Kaufmann

Henry Hongjun Ji

Gunnar Jörg Floris Kaufmann

Ingale Sampat Lalaso

Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.

Cell internalizing compounds

Provided are compounds having the Formula I: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and their use in the intracellular delivery of antibodies.

Intracellular delivery compounds

The present disclosure provides anti-STAT3 antibodies, and antigen-binding portions thereof. In certain embodiments, the antibodies or fragments thereof, are used for the treatment of cancer.

Antibody therapeutics that bind STAT3

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Arcadia, CA, United States of America

Heehyoung Lee