Newtree Co., Ltd.

Biocare Co., Ltd.

Aat Costech Co., Ltd.

Heechul Chung

Jae-Kwan Hwang

Doun Kim

Mi-Bo Kim

Jae Youn Chung

Changhee Kim

Jae-Young Lee

Do Hun Kim

Jae Young Lee

Jeong Hwan Kim

Jeong-Hwan Kim

Chang Hee Kim

Jae Kwan Hwang

Do Un Kim

Jong-hee Sohn

Mi Bo Kim

Hae Ji Lee

Kyu-Lee Han

Se In Lee

Jae-Seok Shim

Ah-Jin Kim

Hyeongmin Kim

Jeong-Han Choo

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing aextract. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating muscle diseases, containing aextract; a food composition for preventing muscle diseases or improving muscular function; or a cosmetic for improving muscular function. Theextract of the present invention increases muscle formation by inducing muscular protein synthesis and muscle cell differentiation. Therefore, the extract is a natural product so as to be used safely without side effects, thereby being usable as an active ingredient of a pharmaceutical, food, or cosmetic composition exhibiting an excellent effect in preventing and treating muscle diseases or improving muscular function.

Composition for preventing and treating muscle diseases or improving muscular function, containing platycodon grandiflorum extract

var.according to the present invention is capable of increasing muscle mass and enhancing muscular function or exercise performance through an effect of promoting mRNA or protein expression and the activity of a gene involved in muscle functions, muscle mass increase of differentiation of muscle cells; can prevent, treat or ameliorate a decline in exercise performance, a decline in muscle function, muscle loss, etc. caused by various diseases; and may be effectively used for medicines or food products, etc., since it has no side effects in the body as natural substance.

Composition for improving muscular function or for enhancing exercise performance comprising vigna angularis var. angularis

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient, at least one selected from the group consisting of morusin, kuwanon G, and a Mori Cortex Radicis extract. The Mori Cortex Radicis extract, morusin, or kuwanon G, according to the present invention, has an effect of remarkably enhancing muscular function by increasing the expression of p-mTOR protein involved in muscular protein synthesis, inhibiting the expression of mRNAs of MuRF-1 and atrogin-1 involved in muscular protein degradation, and increasing the expression of mRNAs of MyoD and myogenin involved in muscular differentiation. In addition, the present invention is a natural product so as to be used safely without side effects, thereby being usable in drugs, food, or cosmetics.

Methods for treating muscle wasting and degeneration diseases

The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

Use of lignan compound for anti-wrinkle treatment

Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.

Method for treating conditions mediated by PPAR using macelignan

Growing community of inventors

Gyeonggi-do, South Korea

Heechul Chung