Daegu-Gyeongbuk Medical Innovation Foundation

Korea Research Institute of Bioscience and Biotechnology

Daegu Gyeongbuk Institute of Science and Technology

Daegu Catholic University Industry Cooperation Foundation

Hee Yoon Ryu

Hwan Geun Choi

So Young Kim

Jung Beom Son

Nam Doo Kim

Yi Kyung Ko

Seungyeon Lee

Seock Yong Kang

Eunhwa Ko

Jin-Hee Park

Sun-Hwa Lee

Dayea Kim

Sun Joo Lee

Sang Bum Kim

Dong Wook Kang

Suk Kyoon Yoon

Sungchan Cho

Jae Hyun Bae

Joong-heui Cho

Eunmi Hong

Hyeon Ho Jeon

Jeong In Kim

Sang Hyun Min

Kyu-Sun Lee

Miri Choi

Ju Yeon Bae

Kweon Yu

Seong Jeong Lee

Ja Wook Koo

Hyang-Sook Hoe

Shinae Kim

Joongheui Cho

Seongho Hong

Hyunkyoung Kim

Jong Yun Jang

Sangbum Kim

Jaeyoung Song

Tae-Ho Jang

Dong Kyu Choi

Sungwoo Lee

Younho Lee

The present invention provides a method for producing high-purity 5-methyl-1H-tetrazole in high yield.

Method for producing 5-methyl-1H-tetrazole

The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases

The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salt thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating the Src and Fyn related diseases, and in particular, have been confirmed to be useful in diabetic nephropathy in animal model experiments. Therefore, the compound of the present invention can be effective as a pharmaceutical composition containing the same as an active ingredient for preventing or treating diabetic nephropathy.

Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer

Growing community of inventors

Daegu, South Korea

Hee Yoon Ryu