Autotac Inc.

Lg Electronics Inc.

Seoul National University

Hee Yeon Kim

Ki Woon Sung

Yong Tae Kwon

Chang Hoon Ji

Srinivasrao Ganipisetti

Su Ran Mun

Chan Hoon Jung

Eui Jung Jung

Su Jin Kim

Ji Eun Lee

Myunghun Im

Jongseok Lee

Min Ju Lee

Chang Min Park

Hyun Tae Kim

Jeong Eun Na

Eun Hye Jeong

The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating misfolded protein diseases comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating selective autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

P62 ligand compound, and composition for preventing, ameliorating or treating proteinopathies comprising the same

One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Cargo delivery system and composition comprising the same

A liquid carbon dioxide base cleaning detergent composition includes: an organic solvent represented by chemical formula 1, and a contaminant remover, where the chemical formula 1 is R—(CH)(CF)—R, m refers to integers from 0 to 4, n refers to integers from 1 to 5, Rand Rrefer to hydrogen H, fluorine F, CH, CHO or CF.

Liquid carbon dioxide-based cleaning composition comprising an organic solvent-based detergent additive

The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

AUTOTAC chimeric compound, and composition for preventing, ameliorating or treating diseases through targeted protein degradation comprising the same

The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Growing community of inventors

Seoul, South Korea

Hee Yeon Kim