Korea Institute of Science and Technology

Orient Bio., Inc.

Hee-Sup Shin

Young-Soo Kim

Dong-Jin Kim

Dae-Soo Kim

Daesoo Kim

Dong-Yun Shin

Sung-Woo Cho

Chan-Ho Park

Chanki Kim

Kye-Jung Shin

Eunice Eun-Kyeong Kim

Key-Sun Kim

Kee-Dal Nam

Hoh-Gyu Hahn

Jungryun Lee

Seon-Hee Seo

Sukchan Lee

Soon-Bang Kang

Sun-Joon Min

Ae-Nim Pae

Hye-Whon Rhim

Gyo-Chang Keum

Chan-Ki Kim

Eun-Joo Roh

Chi-Man Song

Cheol-Ju Lee

Eun-A Kim

He-Sson Chung

Ghil-Soo Nam

Soonwook Choi

Kyung-Il Chol

Sehoon Keum

Inseon Song

Hye-Jin Chung

Hyun-Ah Choo

Yong-Seo Cho

Kee-Hyun Choi

Chan-Seong Cheong

Jae-Kyun Lee

Yong-Koo Kang

Woong-Seo Park

Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's disease, dementia, Parkinson's disease, stroke, amyloidosis, Pick's disease, Lou Gehrig's disease, Huntington's disease, Creutzfeld-Jakob disease, and the like.

Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same

The present invention relates to a novel use of an &#x3b1;1G T-type calcium channel transgenic mouse as a nervous disease model, more particularly, a novel use of a mouse deficient in &#x3b1;1G T-type calcium channel showing novelty-seeking and alcohol preference as a nervous disease model for human nervous related diseases such as novelty-seeking character, alcoholism, anxiety and emotion disorder by stress, etc. The &#x3b1;1G T-type channel transgenic mice showing novelty-seeking and alcohol preference of the present invention can be effectively used for the development of a medicine and a therapeutic method for human nervous diseases.

Mice lacking alpha 1G showing enhanced novelty-seeking and alcohol preference and therapeutic methods for mood disorders by modulating alpha 1G T-type calcium channels

The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1G protein of T-type calcium channels, use of suppressor of alpha 1G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1G subunit of T-type calcium channel, and preparation method thereof. The &#x3b1;1G-knockout transgenic mouse can be used for investigating the relationship between diseases particularly neuropathy or psychopathy and the function of &#x3b1;1G T-type calcium channel via various behavioral tests since &#x3b1;1G subunit is mainly expression in central nervous system (CNS) and pheripheral nervous system (PNS). Further, the &#x3b1;1G-knockout transgenic mouse can be used for screening antileptic agents.

Transgenic mouse whose genome comprises a homozygous disruption of its &#x3b1;1G gene, a method of preparing the same and use thereof

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Uiwang-si, South Korea

Hee-Sup Shin