Korea Hydro Nuclear Power Co., Ltd.

Medifron Dbt Co., Ltd.

Daewoong Pharmaceutical Co., Ltd.

Hee Sun Kim

Seung Jin Choi

Jin Jong Bong

Seok Cheol Shin

Moo Hyun Choi

Hoon Moo Choi

Dong Wook Kang

Young Ho Kim

Chan Mi Joung

Jee Woo Lee

Eun Joo Nam

Kwang Hee Yang

Hee Jin Ha

Hoon Seok Choi

Hyunjin Joo

Dong-Kwon Keum

Hee Youn Shim

Mun Ja Kang

Byulnim Hwang

Dong Kwon Keum

Hyun Soon Bang

Yun-Mi Baek

A method for detecting genes sensitive to low-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to low-level ionizing radiation and related to suppressing thymic cancer, discovered in a carcinogenic entity and verified in a normal entity are detected by subjecting a cancerous AKR/J mouse and a normal ICR mouse to low-level radiation. Thymus is collected therefrom, immunogenic and apoptotic genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, a gene having a specific reaction to radiation can be accurately detected by preventing the interference of confounding variables.

Method for detecting Defb6 gene sensitive to low-level ionizing radiation, and gene detected by the method

Method for detecting Reg3g gene sensitive to low-level ionizing radiation, and gene detected by the method

Method for detecting Tac2 gene sensitive to low-level ionizing radiation, and gene detected by the method

An apoptosis regulatory gene is detected in an irradiated-thymic lymphoma cell by a method for detecting such an apoptosis regulatory gene in a low-dose-rate and low-level-irradiated thymic lymphoma cell of a mouse. This has an effect of revealing the function of an apoptosis regulatory gene by means of irradiation and providing a gene profile, by detecting an apoptosis regulatory gene detected in an irradiated-thymic lymphoma cell. The detected apoptosis regulatory gene is used to construct a gene profile that can assess the dose-response relationship of industrial and healthcare workers living in a low level-radiation environment. The detected apoptosis regulatory gene can be used as an index for evaluating the extent of cancer progression and the degree of treatment in patients with thymic lymphoma. The method for detecting such an apoptosis regulatory gene is used to prepare a composition for diagnosing thymic lymphoma and a diagnostic kit.

Apoptosis regulatory gene detected in irradiated-thymic lymphoma cell and method for detecting same

A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, the present invention allows a gene having a specific reaction to radiation to be accurately detected by preventing the interference of confounding variables.

Method for detecting Acsl1 gene sensitive to high-level ionizing radiation

Method for detecting Scd1 gene sensitive to high-level ionizing radiation

Method for detecting lipe gene sensitive to high-level ionizing radiation

Method for detecting Ppargc1a gene sensitive to high-level ionizing radiation

Disclosed is a detection method for DNA repair-related genes which respond to low-level radiation, which includes the steps of (1) breeding AKR/J mice, as a thymus cancer model, and normal ICR mice in a low-dose radiation environment; (2) collecting thymuses from the AKR/J thymus cancer mouse model and the normal ICR mice which have been bred at the step (1); (3) analyzing genes in the thymuses collected at the step (2); (4) detecting, among the genes analyzed at the step (3), a DNA repair-associated gene expressed commonly or differentially in the AKR/J thymus cancer mouse model and the normal ICR mice; and (5) amplifying the gene detected at the step (4) and measuring the expression level thereof.

Detection method for DNA repair-related genes which respond to low-level radiation

The present invention relates to a Marinelli beaker correction container for stable radionuclide analysis, the Marinelli beaker correction container including: a container body having a diameter corresponding to a detector mounting part provided at a lower part of the Marinelli beaker, and being insertedly mounted to the detector mounting part; a detector coupling groove being formed at a lower part of the container body with an inner diameter corresponding to a diameter of the spectroscopy system detector, and allowing the Marinelli beaker to be mounted on the spectroscopy system detector by insertedly mounting the spectroscopy system detector to the detector coupling groove; and a ventilation hole being vertically formed through a center of a top surface of the container body, and allowing the container body to be smoothly mounted or dismounted due to air ventilation when the container body is mounted to or dismounted from the detector mounting part.

Marinelli beaker correction container for stable radionuclide analysis

Disclosed is a correction container of a Marinelli, wherein a first groove is formed in the lower portion of the container body formed with a diameter corresponding to the inner diameter of the lower surface of the Marinelli beaker, to be attached to a detector of a detecting system for nuclide analysis, a second groove having a diameter smaller than that of the first groove is formed on the upper portion, and an intake and exhaust hole is formed through the first groove to the second groove. According to the present invention, a Marinelli beaker covers a upper portion of a container body to wrap around it, and a detector of a nuclide detecting device is inserted into a first groove formed in a lower portion of the container body. By means of the correction container according to the present invention, the distance between the position of radionuclides in the sample in a Marinelli beaker and the detector is maintained constant. Accordingly, the reliability of the detection value in nuclide analysis is advantageously improved.

Method for detecting genes sensitive to low-level ionizing radiation, and gene detected by the method

A method for detecting genes sensitive to high-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to high-level ionizing radiation discovered in a carcinogenic entity and verified in a normal entity are detected, by subjecting a cancerous AKR/J mouse and a normal ICR mouse to high-level radiation. Thymus is collected therefrom and fatty acid metabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, a gene having a specific reaction to radiation can be accurately detected by preventing the interference of confounding variables.

Method for detecting genes sensitive to high-level ionizing radiation, and gene detected by the method

A method for detecting genes sensitive to low-level ionizing radiation and genes detected by the method. More specifically, genes sensitive to low-level ionizing radiation, discovered in a carcinogenic entity and verified in a normal entity are detected by subjecting a cancerous AKR/J mouse and a normal ICR mouse to low-level radiation. Thymus is collected therefrom, and glycometabolism-related genes are classified via microarray processing of the thymus. The genes are amplified and the levels of gene expression are measured. Thus, a gene having a specific reaction to radiation can be accurately detected by preventing the interference of confounding variables.

Method for detecting genes sensitive to low-level ionizing radiation

Growing community of inventors

Uijeongbu, South Korea

Hee Sun Kim