Hanmi Pharm. Co., Ltd.

Hanmi Science Co., Ltd.

Hanmi Holdings Co., Ltd.

Hee Sook Oh

Tae Hee Ha

Chang Hee Park

Young Hoon Kim

Gwan Sun Lee

Eun Young Kim

Kwee Hyun Suh

Won Jeoung Kim

Sun Young Jang

Hee Seok Kim

Jae Chul Lee

Ji Young Jeon

Kwee-Hyun Suh

Han Kyong Kim

Jae Hyuk Jung

Jong Ouk Baek

Won Jeong Kim

Chang Hee Dongho-Villa 203 Park

Provided are crystalline forms of acid addition salts of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)furo[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide, and a pharmaceutical composition including the same. The crystalline forms may be easily used in preparing the pharmaceutical composition including the same as an active ingredient.

Crystal form of acid addition salt of furopyrimidine compound

A crystalline form of an alkyl benzene sulfonyl urea compound that is useful as an oral antidiabetics is disclosed. Specifically, the compound is a hydrochloride salt of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide of the following formula I. A pharmaceutical composition containing the compound is also disclosed: 

Crystalline forms of hydrochloride salts of thienopyrimidine compound

Disclosed are a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same

This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility and nonhygroscopicity, a method for preparing same, and a pharmaceutical composition containing same.

Optically pure esomeprazole and its salt can be simply prepared by dissolving (S)-(&#x2212;)-binol, a weak base and the racemic form of omeprazole in a mixture of a water-compatible organic solvent and water at a high temperature, cooling the mixed solution to crystallize the inclusion complex of esomeprazole and (S)-(&#x2212;)-binol, and removing the (S)-(&#x2212;)-binol moiety from the crystallized inclusion complex.

Method of preparing esomeprazole and salts thereof

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Seoul, South Korea

Hee Sook Oh