Daewoong Pharmaceutical Co., Ltd.

Daewoong Bio Inc.

Hee Kyoon Yoon

Soo Jin Choi

Byung Goo Lee

In Woo Kim

Ji Duck Kim

Sung Woo Park

Seong Cheol Moon

Sun Ah Jun

Joon Hwan Lee

Youn Jung Yoon

Qing Ri Li

Young Mook Lim

Yeon Jung Yoon

Yoon Seok Song

A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

Method for producing intermediate useful for synthesis of SGLT inhibitor

The present invention relates to an improved method for synthesizing meropenem trihydrate[(1R,5S,6S)-2-[((2'S,4&#x2032;S)-2&#x2032;-dimethylaminocarbozyl)pyrrolidin-4&#x2032;-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic.

Method for preparing meropenem using zinc powder

This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

Method of preparing benzoimidazole derivatives

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Cheongju-si, South Korea

Hee Kyoon Yoon