Daewoong Pharmaceutical Co., Ltd.

The Green Cross Corporation

Hee-kyoon Yoon

Hee Jeong Seo

Se-Hwan Park

Min Ju Kim

Kwang-Seop Song

Soongyu Choi

Eun-Jung Park

Younggyu Kong

So Ok Park

Ji-sung Yoon

Bong-Yong Lee

Jeong-Taek Shin

Wol-Young Kim

Soo-Jin Choi

Byung-Goo Lee

Byung-Jo Lim

Sung-Woo Park

Sun-Ah Jun

Kyung-Ho Lee

The present invention relates to an improved method for producing a diphenylmethane derivative which is effective as a sodium-dependent glucose cotransporter (SGLT) inhibitor, the method being carried out by means of a convergent synthesis method in which each major group is separately synthesized and then coupled. As such, in comparison to a linear synthesis method disclosed in existing documents, the synthesis pathway is compact and yield can be increased, and risk factors inherent in the linear synthesis pathway can be reduced. Furthermore, the crystal form of the compound produced according to the method has superb physicochemical characteristics, and thus can be effectively utilized in fields such as pharmaceutical manufacturing.

Method for producing diphenylmethane derivative

The present invention provides a process for preparing an ertapenem-containing lyophilized formulation, comprising the use of hydroxypropyl &#x3b2;-cyclodextrin as both a cryoprotective agent and a stabilizing agent.

Process for preparing ertapenem-containing lyophilized formulation

Provided is a process for the preparation of meropenem trihydrate in high purity and high yield, including using a dry methanol solvate of meropenem, which can remarkably reduce the amount of residual solvents in the resulting product, thereby obtain meropenem trihydrate in high purity.

Process for preparing meropenem trihydrate

Growing community of inventors

Cheongju-si, South Korea

Hee-kyoon Yoon