Korea Research Institute of Chemical Technology

Dongwha Pharm. Ind. Co., Ltd.

Hee-jung Chung

Yong-ho Chung

Cheol-hae Lee

Bong-jin Kim

Do-kyu Pyun

Won-jang Jeong

Jae-hak Kim

Hyun-jung Kwak

Eun-jung Kim

Shin-seup Song

There is disclosed an azetidinone compound of the formula (I):wherein R is hydrogen, or a hydroxy protecting group, Rand Rare each independently alkyl of 1-15 carbon atoms, benzyl or cyclized together with the carbon atom to which they are attached to form a 5 or 6-membered cyclic hydrocarbon or a heterocyclic radical having one or two hetero ring atoms, said hetero ring atoms being selected from the group consisting of O and S; Ris lower alkyl or &#x2014;COO(lower alkyl) Ris phenyl, or phenyl substituted with halogen, lower alkoxy or nitro which is useful as a synthetic intermediate to the 1'&#x3b2;-methylcarbapenem-type antibacterial agent.

Intermediate of carbapenem antibiotics and process for the preparation thereof

Growing community of inventors

Taejon, South Korea

Hee-jung Chung