Medytox Inc.

Sejong University

Ministry of Food and Drug Safety

Hee Dong Woo

Hyun Ho Jung

Gi Hyeok Yang

Chang Hoon Rhee

Hack Woo Kim

Ki Sung Kwon

Seung Won Kim

Joong Keun Lee

Sang Hoon Ko

Jae Ho Oh

Jung Ah Do

Jung Mu Hur

Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate, and methionine and optionally isoleucine. The liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients, has good storage stability of botulinum toxin at 25˜37° C., as well as at refrigerated temperatures.

Pharmaceutical liquid composition of botulinum toxin with improved stability

Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25&#x2dc;37&#xb0; C. as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without lyophilization process.

Pharmaceutical liquid composition of botulinum toxin with improved stability and method of use

Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25&#x2dc;37&#xb0; C. as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.

Disclosed are a method and a system for estimating food commodity intakes. The method includes (a) obtaining a food intake of a food searched as a subject to be estimated for food commodity intake based on food intake database, (b) obtaining a material mix ratio of the food searched based on the material mix ratio database and estimating a material mix ratio intake using the food intake, (c) detecting whether or not the material contained in the material mix ratio intake estimation results is a food commodity, (d) accumulating a weight data of the material that is detected to be a food commodity among the materials obtained from the material mix ratio intake estimation results, (e) repeatedly performing operations (b) to (d) on materials that are not food commodities, until all of the materials contained in the material mix ratio intake estimation results become food commodities, and (f) summing the accumulated weight data of each food commodity to estimate a food commodity intake of the food, when all of the materials contained in the material mix ratio intake estimation results are food commodities. According to the present invention, more accurate food intake data can be conveniently estimated by converting all ingredients of mixed foods into food commodities.

Method and system for estimating food commodity intake

Disclosed herein is a liquid pharmaceutical composition oftoxin which is improved in stability. It comprisestoxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine astoxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability oftoxin at 25&#x2dc;370C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storingtoxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.

Growing community of inventors

Chungcheongbuk-do, South Korea

Hee Dong Woo