Life Technologies Corporation

Molecular Probes, Inc.

Life Technologies As

Other

Hee Chol Kang

Kyle R Gee

Richard P Haugland

Aimei Chen

Steven Menchen

Geir Fonnum

Dmitriy Gremyachinskiy

Bruce Branchaud

Nini Kjus

Lai-Qiang Ying

Wenjun Zhou

Yi-Zhen Hu

Yexin Wu

Jixiang Liu

Shaheer Khan

Jolene Ann Bradford

Shih-Jung Huang

Brian Lee Evans

Michael O'Grady

James Stray

Robert Aggeler

Gayle Buller

Xin Wang

Michael Wayne Olszowy

Steven L Young

Peter Slade

Bradley Dubbels

Michael H Melner

Quentin Low

Christopher Langsdorf

Yolanda Tennico

Yu-Zhong Zhang

Iain Johnson

Michael A Kuhn

Dieter H Klaubert

Rosaria Haugland

Michael Janes

Richard P Haughland

K Sam Wells

John Michael Brinkley

Yu Zhong Zhang

Bhaskar Mandavilli

Penny Melquist

Nancy Ahnert

Jongtae Yang

Michael Olszowy

Jason Dallwig

Described herein are compounds, methods, and kits for long-term tracking of cell proliferation, differentiation, and/or function. The compounds of the present invention are novel cell-tracking reagents, efficiently excitable with a 405-nm violet laser, that provide bright fluorescence intensity, uniform cell staining, and good retention within cells as well as low toxicity toward cells.

7-hydroxycoumarin-based cell-tracking reagents

The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

Hydrazinyl and aminooxy compounds and their methods of use

Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.

Carbopyronone compounds useful as diagnostic adjuvants

Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Dibenzosilole monomers and polymers and methods for their preparation and use

The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ.

Fluorogenic hydrazine-substituted compounds

A silyl protected diacrylamide compound is described. A method of forming such a compound includes mixing a silylation reagent with a hydroxylated diamine compound under first reactive conditions to form a product in a first solution, separating the product from the first solution, and mixing the product with acryloyl chloride under second reactive conditions in a second solution to form a silyl protected diacrylamide compound.

Hydrophobic diacrylamide compound

Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.

Large stokes shift dyes

Disclosed herein are compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced nucleic acid binding cyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.

Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species

The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R, R, R, Rand L are described throughout the application.

SDP-containing heterobifunctional agents

Growing community of inventors

Eugene, OR, United States of America

Hee Chol Kang