Institut National De La Sante Et De La Recherche Medicale

Sorin Crm Sas

Université De Rennes 1

Universi Ié De Rennes 1

Hector Romero

Jean-Luc Bonnet

Alfredo Hernandez

Guy Carrault

Virginie Le Rolle

An active implantable medical device for neurostimulation therapy is disclosed. The device produces stimulation pulse sequences generated continuously in succession during activity periods separated by intermediate inactivity periods during which no stimulation is issued. An input signal, provided by a physiological sensor, representative of cardiac activity and/or of the patient's hemodynamic status is received by circuitry. The circuitry further provides for dynamic control of the neurostimulation therapy, wherein the length of activity periods is modulated based on the current value level of the control parameter compared to a threshold. The duration of the next period of inactivity is calculated by the circuitry at the end of each activity period to maintain a constant duty cycle ratio between periods of activity and periods of inactivity.

Active implantable medical device for nerve stimulation therapy with dynamic adjustment of stimulation periods

One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to the rules on physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

System for stimulation therapy of the vagus nerve by implementation of a self-adaptive state transition model based on physical or physiological levels

System for stimulation therapy of the vagus nerve by implementation of a state transition model operating at multiple temporal or spatial resolutions

One system includes a stimulation device such as a vagus nerve stimulation lead, and a controller for controlling the stimulation device according to a set of stimulation parameters. A memory of the stimulation device contains a state transition model, and for each state defines a set of stimulation parameters and at least one expected response during the application of stimulation with the parameters. A matrix determines the transition rules between states based on physiological levels measured versus target levels. A state transition control unit determines, in an organized timely method, possible transitions between states according to rules on the physiological levels obtained in response to the implementation of the stimulation parameters of the current state, and a transition from a current state to a new state causes a corresponding change in the parameter set used for stimulation.

System for stimulation therapy of the vagus nerve by implementation of a state transition model

System for stimulation therapy of the vagus nerve by implementation of a state transition model with a learning phase

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Rennes, France

Hector Romero