Corixa Corporation

Heather Secrist

Michael J Lodes

Steven G Reed

Raodoh Mohamath

Darin R Benson

Jiangchun Xu

Patricia Dianne McNeill

Raymond L Houghton

Tongtong Wang

Robert A Henderson

John A Stolk

Paul R Sleath

Madeleine Joy Meagher

Mary J Homer

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Compositions and methods for the therapy and diagnosis of lung cancer

Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Compounds for immunotherapy and diagnosis of colon cancer and methods for their use

Compounds and methods for the diagnosis and treatment of infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

Compounds and methods for the diagnosis and treatment of B. microti infection

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Compounds for therapy and diagnosis of lung cancer and methods for their use

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Seattle, WA, United States of America

Heather Secrist