Beth Israel Deaconess Medical Center, Inc.

Heather R Christofk

Lewis C Cantley

Matthew G Vander Heiden

The invention provides pharmaceutical compositions, kits, and methods of treating cancer, diabetes, obesity, autoimmune disease, and benign prostatic hyperplasia using compounds that selectively inhibit pyruvate kinase M2 and an assay measuring chemical modulation of pyruvate kinase activity.

Inhibitors of pyruvate kinase and methods of treating disease

The invention described herein features methods, compositions, and kits for the use of activators of PKM2 for the treatment, prevention, or amelioration of diseases related to PKM2 function, including, e.g., cancer, diabetes, atherosclerosis, restenosis, obesity, autoimmune disorders, and proliferative disorders.

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Carlsbad, CA, United States of America

Heather R Christofk