Quantumdx Group Limited

Heather Murton

Eduardo Boada

Jonathan James O'Halloran

Jonathan Salmon

Stephen Osborne

Lothar Schmid

Jonathan O'HALLORAN

Microfluidic device having a plurality of microfluidic channels and corresponding dielectrophoresis (DEP) electrode arrays, each channel arranged to direct fluid over a DEP electrode array such that in use target particles are manipulated by the DEP electrode array. The device also has a first connection point and second connection point for connecting the device to an alternating current source, a first input of each DEP electrode array connected to the first connection point via the first conductor and second input of each DEP electrode array connected to the second connection point via the second conductor. A resistance of the first conductor between the first input of each electrode and the first connection point, and a resistance of the second conductor between the second input of each electrode and the second connection point is substantially at least an order of magnitude less than a total resistance of the connected electrode arrays.

Microfluidic device with DEP arrays

Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.

Target cell concentration using dielectrophoresis (DEP)

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Newcastle upon Tyne, United Kingdom

Heather Murton