Ortho-Clinical Diagnostics, Inc

Heather Lane-Brown

Banumathi Sankaran

Jian Zheng

Edward R Scalice

George Bashirians

Deborah Byrne

Sarah Groulx

Sharon Jackson

Karen Yang

Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to a disease such as vascular, vascular-related disease, cardiac, cardiac-related disease, cancer, cancer-related disease, preeclampsia, and preeclampsia-related disease. Determining sFlt-1:angiogenic factor complex is particularly useful for predicting and detecting preeclampsia in early stages of gestation and in stages of the disease where clinical evaluation may be uninformative.

Determination of sFlt-1:angiogenic factor complex

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Honeoye Falls, NY, United States of America

Heather Lane-Brown