Investigen, Inc.

Affymetrix, Inc.

Levgo, Inc.

Other

Investigen Biotechnologies, Inc.

Heather Koshinsky

Michael Steven Zwick

John D Curry

Brian David Warner

Rachel Anne Holmes-Davis

Kent F McCue

Philip H Dickinson

Adam McCoy

Daniel Fitzpatrick

Margret Elaine Leventhal

Miaomiao Wang

Robert O'Callahan

Charles Robert Bupp, Ii

Amanda Kay Lindholm-Perry

Richard Mark Thallman

K Yeon Choi

Anthony C Schweitzer

Mickey S Urdea

Maiomiao Wang

Rick Blidner

Zbigniew Rafinski

Beata Anna Jedrzejewska

Jerzy Paczkowski

Alexander Hunt

Margret Leventhal

Alexander Izmailov

Christopher Jon Nulf

Disclosed are compositions, methods and kits for determining the presence, absence, amount, copy number, or other characteristics of one or more polynucleotide sequences in two or more samples and use thereof in genotyping, evaluation of copy number variation, expression analysis, determination of splice variants and fusion genes, and other genetic analyses.

Nucleic acid analysis by joining barcoded polynucleotide probes

A device is provided for supplying a fluid to a cut plant. The device includes a container comprising a base and a surrounding wall extending from the base to define an enclosed space or cavity for holding the fluid. The device also includes a connector coupled to the container. The device further includes a flexible tube coupled to the connector at a first end and having a jagged open end, wherein the connector enables a fluid communication between the container and the flexible tube. A system is provided that includes such a device, a holder for the cut plant, and a fastener to secure the flexible tube to the holder. The flexible tube extends into the holder to allow the fluid to flow from the container to the holder, such that a fluid level in the container is the same as a fluid level in the holder.

Devices for supplying fluids to cut plant holders

A device for supporting a laboratory object is provided. The device may comprise a body extending about and defining an opening. The body may be positioned in a customized orientation selected from a plurality of orientations. The device may include a first support defined by the body and configured to contact a surface when the body is in a first orientation. The device may include a second support coupled to the first support. The second support may be configured to contact the surface when the body is in a second orientation.

Laboratory device

A method for detecting the presence or absence of a target polynucleotide in a sample is described.

Methods of determining the presence or absence of a plurality of target polynucleotides in a sample

The disclosure provides a method of determining the presence or absence of a plurality of target polynucleotides in a sample including combining a sample that may comprise one or more of the plurality of target polynucleotides with a plurality of sets of complementary polynucleotides; incubating the polynucleotides under conditions that allow hybridization of complementary sequences; joining the first and second complementary polynucleotides to form one or more product polynucleotides; and detecting the presence or absence of one or more product polynucleotides to determine the presence or absence of one or more of the plurality of target polynucleotides in the sample.

Laboratory spatula having stalk regions with a hollow first end and a hollow second end and at manipulating regions may be used for collecting, transporting or storing a material. A manipulating region may be configured as a shovel region, a scoop region, a whisk region, a punch region, a sieve region, a loop region, a cutting edge, a spreading region, a grinding region, a hook region, a scraper region, a tweezer region, a grasper region, or a pick region. The spatula may be lightweight and disposable, and may be any appropriate size including micro size, a regular size, or a macro size. The spatula may also have an anti-stick surface. The spatula may be calibrated, and may include calibration marks or additional features.

Laboratory spatula

Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

Methods and compositions for detecting polynucleotides

The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic acid analog, a nucleic acid analog specific binding substrate and a light reactive dye with a light stimulus, and detecting the presence or absence or amount of a reaction product of the catalytic complex and light stimulus. The present invention also relates to a method of assaying a nucleic acid analyte in a sample using an analyte-specific reporter complex. The present invention also relates to a method of assaying an analyte in a sample using a reporter molecule.

Assays based on detection of photobleaching reaction products from dye catalytic complex

The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is specifically directed to novel approaches for capturing, separating and releasing such target molecules.

Methods and compositions for rapid light-activated isolation and detection of analytes

The present invention relates to methods for detecting the presence or amount of a target polynucleotide. A polynucleotide, target nucleic acid analog, and dye are combined to form a mixture. The optical property of the dye is observed after the mixture is exposed to a stimulating means. Optionally, after the stimulating means is employed, the mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar mixture containing a known amount of a target polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The change in a property of the mixture after exposure thereof to a stimulating means or the relative rate of change in the optical property of dye in the mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

System for detecting polynucleotides

A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

Growing community of inventors

El Cerrito, CA, United States of America

Heather Koshinsky